Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome

The American Journal of Cardiology
S M Grundy

Abstract

The importance of high serum cholesterol, especially a high level of low-density lipoprotein (LDL) cholesterol, as a risk factor for coronary artery disease is well established. Likewise, efficacy for decreasing risk for coronary artery disease by LDL-lowering therapy has recently been documented through clinical trials. However, many high-risk patients manifest elevated serum triglyceride levels, and the role of hypertriglyceridemia in causation of coronary artery disease remains to be elucidated. Nonetheless, there is growing evidence that hypertriglyceridemia is a marker for increased risk for coronary artery disease; in fact, it can serve as a marker for several atherogenic factors. These factors include increased concentrations of atherogenic triglyceride-rich lipoproteins; the atherogenic lipoprotein phenotype, or lipid triad; and the metabolic syndrome. The lipid triad consists of elevated serum triglycerides, small LDL particles, and low high-density lipoprotein (HDL) cholesterol. The metabolic syndrome includes the coexistence of the lipid triad, elevated blood pressure, insulin resistance (plus glucose intolerance), and a prothrombotic state. Many previous studies indicate that hypertriglyceridemia is strongly associa...Continue Reading

References

Aug 19, 1978·Lancet·E J SchaeferW C Blackwelder
Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E L Bierman
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A Austin
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Feb 1, 1990·Diabetes Care·A Garg, S M Grundy
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G L Vega, S M Grundy
Jun 1, 1990·Archives of Internal Medicine·G L Vega, S M Grundy
Feb 1, 1990·Metabolism: Clinical and Experimental·T PollareC Berne
Jul 1, 1988·Annals of Internal Medicine·C EastS M Grundy
Jan 14, 1988·The New England Journal of Medicine·A Garg, S M Grundy
Dec 1, 1986·Journal of the American College of Cardiology·P L CannerW Friedewald
Dec 1, 1982·Annals of Internal Medicine·A D SnidermanP O Kwiterovich
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FagerG Bondjers
Sep 1, 1994·Diabetologia·P J RandleA Halsall
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S PlumpJ L Breslow
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LeeR H Unger
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y NakashimaR Ross
Aug 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·B BladesS M Grundy
Feb 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A ZambonJ D Brunzell
Apr 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G L Vega, S M Grundy

❮ Previous
Next ❯

Citations

Mar 12, 2013·Journal of Pregnancy·Bonnie BrensekeJ Claudio Gutierrez
Dec 14, 2011·Clinical Lipidology·Danyaal S Moin, Anand Rohatgi
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W R OliverT M Willson
Jul 15, 2006·Journal of Endocrinological Investigation·S GreieW Schobersberger
Jan 12, 2001·The American Journal of Cardiology·W Castelli
Jul 27, 2001·The American Journal of Cardiology·C M BallantyneUNKNOWN ACCESS Study Group. Atorvastatin Comparative Cholesterol Efficacy and Safety Study
Jul 13, 2012·Canadian Journal of Physiology and Pharmacology·Niraj M BhattSarita Gupta
Oct 23, 2002·Journal of General Internal Medicine·Michael L Green
Feb 21, 2004·BMC Genetics·Marsha A WilcoxLindsay A Farrer
Feb 21, 2004·BMC Genetics·Agustin G YipDiego F Wyszynski
Oct 1, 2005·Lipids in Health and Disease·Malini MadhavanJasjeet S Wasir
Apr 2, 2009·Lipids in Health and Disease·Antonio López-RuizAntonio Hernández-Mijares
Nov 9, 2010·Vascular Health and Risk Management·Christina VoulgariNicholas Tentolouris
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Lúcia C N ErberichMarileia Scartezini
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Mehdi RasouliVahid Mokhberi
Sep 21, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miroslava ZamaklarTatjana Potpara
Mar 29, 2001·Current Hypertension Reports·F RamosR Sánchez
Jun 25, 2005·The British Journal of Nutrition·Arja T ErkkiläSarah L Booth
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Roberto MiccoliStefano Del Prato
Sep 12, 2012·Current Cardiology Reports·Ian GrahamZeljko Reiner
Sep 20, 2007·Current Atherosclerosis Reports·Ngoc-Anh Le, Mary F Walter
Dec 21, 2000·Current Atherosclerosis Reports·S Gehrisch
Aug 19, 2008·Current Atherosclerosis Reports·Patrick McBride

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.