PMID: 9181461May 1, 1997Paper

Hypertriglyceridemia during long-term interferon-alpha therapy in a series of hematologic patients

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
D SgarabottoA Girolami

Abstract

Adverse reactions to interferon-alpha (IFN-alpha) therapy include flu-like syndrome, bone marrow suppression, neurotoxic effects, and autoimmunity. A slight increase in triglyceride levels has been described less frequently during IFN-alpha administration. The incidence of IFN-alpha-induced hypertriglyceridemia seems variable, and there are no clear data on how to treat it. We report the effect of long-term (more than 12 months) IFN-alpha treatment on triglyceride levels in 43 patients suffering from hairy cell leukemia (18), multiple myeloma (10), chronic myelogenous leukemia (6), cryoglobulinemia (5), non-Hodgkin's lymphoma (3), and Sezary syndrome (1). Hypertriglyceridemia was found in 6 patients (15%). In 3 patients, gemfibrozil restored normal triglyceride values. This study suggests that hypertriglyceridemia is a minor side effect of long-term IFN-alpha therapy and that gemfibrozil might be considered the treatment of choice.

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Citations

Apr 24, 1999·The British Journal of Dermatology·V Junghans, T M Rünger
Aug 12, 2004·The Annals of Pharmacotherapy·Siu-Fun WongReza Taheri
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John M KirkwoodLori Stover

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