Hypertrophic cardiomyopathy in the elderly

Geriatrics & Gerontology International
Toru KuboYoshinori L Doi

Abstract

Hypertrophic cardiomyopathy (HCM) is a relatively common genetic cardiac disorder with heterogeneous morphological, functional and clinical features. Although the risk of sudden death and incapacitating symptoms in young patients has been focused upon, the disease has been found with increasing frequency in elderly patients. However, there have been few studies on clinical features of HCM in the elderly. We established a cardiomyopathy registration study in Kochi Prefecture, which is one of the most aged communities in Japan, to provide detailed descriptions of the clinical features of HCM in a community-based patient cohort. The unselected regional HCM population consisted largely of elderly patients (70% of the study cohort being >or=60 years of age at registration), although HCM has been regarded largely as a disease of the young. Cardiac hypertrophy that becomes clinically apparent late in life can be a genetic disorder, and mutations in the cardiac myosin-binding protein C gene are the most common cause of late-onset or elderly HCM. In the morphological features, sarcomere gene defects seem to have a predilection for a crescent-shaped left ventricular cavity with reversed septal curvature even in elderly patients, although...Continue Reading

References

Mar 1, 1991·Journal of the American College of Cardiology·C SeilerH P Krayenbuehl
May 1, 1990·British Heart Journal·L M Shapiro
Nov 15, 1995·Journal of the American College of Cardiology·F CecchiB J Maron
Jun 1, 1994·The American Journal of Cardiology·J F Lewis, B J Maron
Mar 13, 1997·The New England Journal of Medicine·P SpiritoB J Maron
Jul 31, 1997·The New England Journal of Medicine·H SeggewissL Faber
Sep 19, 1998·Circulation Research·G BonneK Schwartz
Feb 24, 1999·JAMA : the Journal of the American Medical Association·B J MaronD M Aeppli
Dec 29, 2000·Journal of the American College of Cardiology·P M ElliottW J McKenna
Jan 15, 2002·Journal of the American College of Cardiology·Barry J MaronPaolo Spirito
Jan 30, 2002·Circulation·Hideshi NiimuraChristine E Seidman
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Barry J Maron
Sep 6, 2003·Journal of the American College of Cardiology·Barry J MaronDorothee M Aeppli
Sep 11, 2004·Journal of the American College of Cardiology·Sara L Van DriestMichael J Ackerman
Nov 3, 2004·Journal of the American College of Cardiology·Sara L Van DriestMichael J Ackerman
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Ferhaan AhmadChristine E Seidman
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayoshi HirotaYoshinori L Doi
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KitaokaYoshinori L Doi
Nov 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayuki NagaiJitsuo Higaki
Sep 6, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Akinori Kimura
Jul 11, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru KuboYoshinori L Doi

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Citations

Aug 25, 2015·The American Journal of Medicine·Edgar ArgulianFranz H Messerli
Mar 30, 2016·Archivos de cardiología de México·Delicia Gentille-Lorente, Teresa Salvadó-Usach
Nov 26, 2011·Journal of the American College of Cardiology·Eline A NannenbergEric J G Sijbrands
Nov 8, 2016·Journal of the Neurological Sciences·Jan KobalZiva Melik
Feb 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jul 17, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KitaokaYoshinori L Doi

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