Hypertrophic effect of inhaled beta2 -agonist with and without concurrent exercise training: A randomized controlled trial

Scandinavian Journal of Medicine & Science in Sports
S JessenMorten Hostrup

Abstract

Due to a high prevalence of asthma and exercise-induced bronchoconstriction in elite athletes, there is a high use of beta2 -adrenoceptor agonists (beta2 -agonists) in the athletic population. While anabolic in rodents, no study has been able to detect hypertrophy in humans after chronic beta2 -agonist inhalation. We investigated whether inhaled beta2 -agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men. Sixty-seven participants completed a 4-week intervention of daily terbutaline (8 × 0.5 mg) or placebo treatment without concurrent training (habitual; n = 23), with resistance (n = 23) or endurance (n = 21) training 3 times weekly. Before and after the interventions, participant's body composition was determined by dual-energy X-ray absorptiometry and resting metabolic rate and substrate oxidation by indirect calorimetry. Terbutaline increased lean body mass by 1.03 kg (95% CI 0.29-1.76; P < .05) and 1.04 kg (95% CI 0.16-1.93; P < .05) compared to placebo in the habitual and resistance training group, respectively, but had no effect compared to placebo in the endurance training group [-0.56 kg (95% CI -1.74-0.62; P > .05)]. Fat mass, bone mineral co...Continue Reading

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Citations

Oct 30, 2018·Bioanalysis·Florence R WangKalmorat Metavarayuth
Nov 30, 2018·Drug Testing and Analysis·Mario ThevisHans Geyer
Dec 21, 2018·International Journal of Sports Physiology and Performance·John MolphyGregory Whyte
Apr 9, 2019·International Journal of Sports Physiology and Performance·Michele MerliniJohn Dickinson
Nov 15, 2019·Drug Testing and Analysis·Mario ThevisHans Geyer
Jan 22, 2020·Drug Testing and Analysis·Morten HostrupAnders Krogh Lemminger
Apr 22, 2020·Drug Testing and Analysis·Glenn A Jacobson, Morten Hostrup
Aug 24, 2019·Scandinavian Journal of Medicine & Science in Sports·Anders Krogh LemmingerMorten Hostrup
Feb 12, 2021·Scientific Reports·Naoki KuramotoWataru Ogawa
Oct 23, 2021·The Journal of Physiology·Morten Hostrup, Johan Onslev

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