PMID: 22570900Mar 15, 2000Paper

Hypertrophic muscular dystrophy in a young dog

Journal of the American Veterinary Medical Association
C A WettermanG D Shelton

Abstract

Hypertrophic muscular dystrophy was diagnosed in a 10-month-old male Rat Terrier with hypersalivation, dysphagia, gait abnormalities, and generalized weakness. Serum creatine kinase activity was high, and electromyography revealed myotonic discharges. Histologic examination of a muscle biopsy specimen revealed muscle fiber degeneration, clusters of basophilic regenerating fibers, and endomysial fibrosis. Staining for dystrophin, a sarcolemmal protein, was decreased, compared with that in muscle specimens from clinically normal dogs. Treatment with mexilitene hydrochloride and procainimide hydrochloride resulted in temporary improvement in clinical signs, but the disease became refractory to treatment, and the dog was euthanatized. Clinical and histologic characteristics of this dystrophin deficiency-related muscular dystrophy were similar to those of X-linked muscular dystrophy in dogs, hypertrophic muscular dystrophy in cats, and Duchenne muscular dystrophy in humans.

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Citations

Jan 7, 2004·Journal of the Neurological Sciences·Boyd R JonesG Diane Shelton
Mar 29, 2008·Journal of Veterinary Internal Medicine·K DeitzG D Shelton
Feb 18, 2014·Journal of Comparative Pathology·A B BaroncelliO Paciello
Feb 8, 2005·Neuromuscular Disorders : NMD·G Diane Shelton, Eva Engvall
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·Scott J Schatzberg, G Diane Shelton
Jan 28, 2015·The Journal of Small Animal Practice·C GiannasiV Palus
Feb 25, 2015·Human Gene Therapy. Clinical Development·Dongsheng Duan
Aug 18, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Bruce F SmithDongsheng Duan
May 23, 2002·Journal of the American Animal Hospital Association·Robert L BergmanG Diane Shelton
Jul 7, 2007·Journal of the American Animal Hospital Association·Wendy Irene BaltzerJoerg M Steiner
Dec 29, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Peter P NghiemJoe N Kornegay
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·G Diane Shelton, Eva Engvall

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