PMID: 15227134Jun 1, 1983Paper

Hypertrophic obstructive cardiomyopathy: hemodynamic improvement with intravenous verapamil

Texas Heart Institute Journal
S J RothL A Latson

Abstract

We report the reduction in left ventricular outflow tract gradient following the intravenous administration of verapamil to two pediatric patients with hypertrophic obstructive cardiomyopathy. Traditional therapy with beta adrenergic antagonists was relatively contraindicated in both patients. In a 15-year-old patient, the left ventricular outflow tract gradient decreased from 160 torr, at rest, to 45 torr during the verapamil infusion. In a 3-year-old boy, there was a reduction in the left ventricular outflow tract gradient from 60 torr, under basal conditions, to 10 torr during the intravenous verapamil infusion. We believe that verapamil may be effective in reducing the left ventricular outflow tract gradient in some pediatric patients with hypertrophic obstructive cardiomyopathy and may be useful in treating selected patients with this disorder.

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.