PMID: 8583319Nov 1, 1995Paper

Hypertrophic pyloric stenosis: ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal

Journal of Pediatric Surgery
J C LangerE E Daniel

Abstract

Dysfunction of pyloric inhibition has been implicated in the pathophysiology of hypertrophic pyloric stenosis. Normal inhibition likely is mediated by peptidergic enteric nerves and also may involve interstitial cells of Cajal (ICC). The authors used electron microscopy to qualitatively assess these structures in infants with pyloric stenosis and in normal controls. Pyloric muscle strips from five infants with hypertrophic pyloric stenosis, from three normal pediatric organ donors, and from three adults were examined. The following observations were made. (1) Muscle cells were primarily in a proliferative phase in pyloric stenosis and exhibited very few gap junctions between smooth muscle cells or ICC compared with the control specimens. (2) The circular muscle layer in pyloric stenosis was characterized by near absence of large granular vesicle-containing nerve fibers compared with the control specimens. (3) There were fewer nerve cell bodies in the myenteric plexus in pyloric stenosis, and the total number of ganglia was lower than that in control samples. (4) Interstitial cells of Cajal were almost completely absent in patients with hypertrophic pyloric stenosis, but there was a group of cells resembling ICC that was termed ...Continue Reading

References

Feb 1, 1976·Journal of Pediatric Surgery·L Spitz, S S Zail
Aug 20, 1992·The New England Journal of Medicine·J M VanderwindenM H De Laet
Jul 1, 1990·Canadian Journal of Physiology and Pharmacology·I BerezinE E Daniel
Jan 1, 1990·Acta Neuropathologica·R DielerG Steinau
Mar 1, 1990·Canadian Journal of Physiology and Pharmacology·J D HuizingaE Chow
Sep 1, 1985·The Anatomical Record·H B MikkelsenN Thorball
Apr 1, 1986·Journal of Pediatric Surgery·G Malmfors, F Sundler
Jul 1, 1989·Archives of Histology and Cytology·S KobayashiS Pompolo
Dec 1, 1989·Canadian Journal of Physiology and Pharmacology·E E DanielV Posey-Daniel
Jan 1, 1989·Acta Neuropathologica·R Dieler, J M Schröder
Jul 1, 1988·The Journal of Physiology·H D AllescherF Kostolanska
Oct 1, 1961·Archives of Disease in Childhood·J R RINTOUL, N F KIRKMAN

❮ Previous
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Citations

May 19, 2009·Pediatric Radiology·Marta Hernanz-Schulman
Mar 30, 2012·Pediatric Radiology·Jeffrey P OtjenMarguerite T Parisi
Oct 13, 2006·Pediatric Surgery International·W SherwoodK Lakhoo
Oct 31, 2007·Pediatric Surgery International·Udo RollePrem Puri
Sep 18, 2009·Pediatric Surgery International·Christina Panteli
Mar 27, 2007·Cell and Tissue Research·Xuan-Yu WangJan D Huizinga
Dec 23, 1998·Journal of the Autonomic Nervous System·R HaggerD Kumar
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·N HudsonG Pearson
Jun 18, 2009·The Journal of Biological Chemistry·Mira M WoutersGianrico Farrugia
Oct 1, 2004·ANZ Journal of Surgery·Sebastian K KingBridget R Southwell
Dec 22, 1999·Archives of Histology and Cytology·T KomuroK Horiguchi
May 11, 2002·Archives of Histology and Cytology·Ichiro TakayamaShinichi Ohno
Nov 15, 2008·World Journal of Gastroenterology : WJG·Lucian M NegreanuCatalin Cirstoiu
Jul 9, 2010·World Journal of Gastroenterology : WJG·Randa-M MostafaHosam Hamdy
Mar 23, 2013·African Journal of Paediatric Surgery : AJPS·Fariba Tabrizian NaminiMostafa Mirzade
Jan 16, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Othman A Al-Shboul
Mar 15, 2003·Radiology·Marta Hernanz-Schulman
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E E Daniel, Y F Wang
Nov 2, 2007·Advances in Surgery·Daniel J Ostlie, George W Holcomb
Jan 11, 2007·Seminars in Pediatric Surgery·Gudrun Aspelund, Jacob C Langer
Jul 10, 2007·Anatomia, histologia, embryologia·K M G De CeulaerA Weyns
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Farrugia
Jun 9, 2010·Equine Veterinary Journal·C Fintl, N P H Hudson
Feb 4, 1998·Baillière's Clinical Gastroenterology·M Thomson
Aug 31, 1999·Journal of Pediatric Surgery·S E KennyC Vaillant
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Michaël MaesMathieu Vinken
Dec 2, 2008·Journal of Pediatric Surgery·Marie-Chantal StruijsPaul W Wales
Jan 26, 2002·The American Journal of Gastroenterology·Christophe PorcherSean M Ward
Jan 19, 2000·The American Journal of Gastroenterology·W M SunM Horowitz
Feb 3, 1999·The American Journal of Emergency Medicine·K PapadakisF G DeLuca
Sep 15, 2011·Tropical Doctor·P W Saula, G P Hadley
Aug 5, 2016·Physiology·Kenton M SandersSean M Ward
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Apr 1, 1997·The British Journal of Surgery·R HaggerD Kumar
Apr 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuan-Yu WangJan D Huizinga
Oct 17, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred Hauben, Guy W Amsden
Apr 24, 2008·Journal of Cellular and Molecular Medicine·Jieyun Yin, Jiande D Z Chen
Jul 6, 2014·Physiological Reviews·Kenton M SandersSang Don Koh

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