Hypertrophy of intima media of the carotid artery due to L-dopa therapy in Parkinson's disease

Advances in Therapy
Cağatay OncelDerya Uludüz

Abstract

Recent studies have shown that L-dopa therapy used in patients with Parkinson's disease might cause thickening of the carotid artery intima media. It is known that intima-media thickening is a sign of systemic atherosclerosis. The purpose of this study was to clarify the correlation between L-dopa medication and carotid artery intima-media thickness (IMT) in patients with Parkinson's disease. Twenty-five patients with Parkinson's disease who used L-dopa (LD+) and 17 patients who did not use L-dopa (LD-) treatment were included in this study. Colour Doppler with B-mode carotid ultrasonography was performed. The Hoehn-Yahr scale was used for staging of Parkinson's disease in an 'on' state. The Student t test was used for statistical analysis. The IMT of the left internal carotid and external carotid arteries were found to be thicker in patients treated with L-dopa. The mean IMT of the left internal carotid artery was 0.937+/-0.391 mm in the LD+ group and 0.677+/-0.138 mm in the LD-group (P=0.013). The mean IMT of the left external carotid artery was 0.956+/-0.531 mm in the LD+ group and 0.646+/-0.18 mm in the LD-group (P=0.037). The IMT of the carotid artery was found to be thicker in patients who were treated with L-dopa. In con...Continue Reading

References

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Citations

Mar 21, 2018·Experimental Aging Research·Mahmoud A AlomariEsraa H Dersieh
Jun 16, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Samay JainWill T Longstreth
May 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Mariana AlvesJoaquim J Ferreira

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