PMID: 8962592May 1, 1996Paper

Hypertrophy of the cerebral white matter in hemimegalencephaly

Pediatric Neurology
M KatoS Takashima

Abstract

We morphometrically measured the cut surface of the cerebral hemisphere and localized epidermal growth factor (EGF)-like immunoreactivity in 4 patients with hemimegalencephaly. On the affected side, the area of cerebral white matter was more than twice as large as that on the unaffected side, while the area of the cerebral cortex on the affected side was relatively small. EGF-like immunoreactivity was demonstrated in cortical neurons (4 of 4 patients) and glial cells (3 of 4 patients), notably in astrocytes. Significant enlargement of the cerebral white matter compared to the cerebral cortex and the expression of EGF-like molecules in astrocytes suggest excessive proliferation in the white matter with hemimegalencephaly and the possible relevance of EGF to these events.

References

May 1, 1991·Molecular and Cellular Endocrinology·P R GoodyerC G Goodyer
Mar 1, 1991·Developmental Medicine and Child Neurology·R AppletonD Mendelow
Nov 1, 1990·Neuropediatrics·R CusmaiB Echenne
Jan 1, 1989·Acta Neuropathologica·O RobainO Dulac
May 1, 1988·Acta paediatrica Scandinavica·A PesericoP Drigo
Mar 1, 1988·Neuropathology and Applied Neurobiology·O RobainF Rozenberg
Jan 1, 1984·Brain & Development·M DambskaJ H Sher
Aug 1, 1981·Annals of Neurology·T Furukawa, T Shinohara
Nov 1, 1995·Journal of Neuroscience Research·M KatoS Takashima

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Citations

Mar 20, 2010·Acta Neuropathologica·Branavan Manoranjan, John P Provias
Feb 1, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eleonora Aronica, Peter B Crino
Dec 17, 2014·Annals of Indian Academy of Neurology·Leema PaulineVenkatesan Prasanna Eswaradass
Apr 14, 2012·Brain Pathology·Eleonora AronicaRoberto Spreafico
Jun 1, 2013·Neuroscience Letters·Mitsutoshi MunakataShigeo Kure
Dec 31, 2003·Journal of Child Neurology·Laura Flores-SarnatAntonio Alvarez
Jun 1, 2005·Journal of Child Neurology·Masayuki SasakiKenji Sugai
Aug 2, 2002·Journal of Child Neurology·Laura Flores-Sarnat
Oct 21, 2015·The Neuroradiology Journal·Tomomi OikawaShoki Takahashi
Sep 6, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·T E Herman, M J Siegel

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