Hyperuricaemia and preeclampsia: is there a pathogenic link?

Medical Hypotheses
R C Schackis

Abstract

A hypothesis, based on animal studies and human observational studies, was developed proposing a direct pathogenic link between hyperuricemia and preeclampsia. Epidemiological characteristics of preeclampsia such as its uniqueness to humans and an increased incidence of preeclampsia in multiple pregnancies, increased body mass index, renal and hypertensive disease all have uric acid as their common denominator. Animal studies have linked hyperuricaemia to hypertensive, cardiovascular and renal disease. The aim of the study was to determine whether lowering the serum uric acid levels in preeclampsia would affect biochemical parameters and hypertensive control. A randomized, double-blind, placebo controlled study. A tertiary referral center. Forty women with preeclampsia between 26 and 32 weeks gestation. Probenecid 250 mg twice daily for seven days. Renal function and haematological parameters, hypertensive control. In the Probenecid group, there was a significant drop in the serum uric acid levels. Lower uric acid levels in the Probenecid group had no significant effect on blood pressure. Patients in the Probenecid group had a significantly lower serum creatinine value at the end of the study when compared to patients in the pl...Continue Reading

References

Dec 1, 1977·British Journal of Obstetrics and Gynaecology·C W RedmanR H Wilkinson
Apr 15, 1976·American Journal of Obstetrics and Gynecology·J A PritchardR A Mason
Mar 1, 1992·American Journal of Obstetrics and Gynecology·B A ClarkF H Epstein
May 1, 1990·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R A Fay
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Oct 1, 1988·American Journal of Obstetrics and Gynecology·G M RodgersJ M Roberts
Apr 1, 1988·American Journal of Obstetrics and Gynecology·D A Davey, I MacGillivray
May 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H GraeffR Schröck
Jan 1, 1981·Contributions to Nephrology·H RiedelG M Eisenbach
Jan 1, 1996·Journal of Biochemical Toxicology·M A Abou-Seif
Jul 9, 1998·Seminars in Reproductive Endocrinology·J M Roberts
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·C A Hubel
Dec 22, 1999·American Journal of Obstetrics and Gynecology·J ZhangP Moyer
Jan 12, 2001·Obstetrics and Gynecology·R L FischerM L Hediger
Apr 19, 2002·Molecular Biology and Evolution·Masako OdaNaoyuki Takahata
May 9, 2002·American Journal of Physiology. Renal Physiology·Marilda MazzaliRichard J Johnson
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Ashley JeffersonRichard J Johnson
Jul 10, 2002·Circulation·Colin A J FarquharsonAllan D Struthers
Aug 9, 2002·Renal Failure·Mohammad AbdelrahmanAyman Karkar
Aug 24, 2002·American Journal of Obstetrics and Gynecology·Dorothea MostelloTerry Leet
Sep 7, 2002·Hypertension·Susumu WatanabeRichard J Johnson
Oct 9, 2002·The Journal of Clinical Hypertension·Julían SeguraLuis M Ruilope
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Laura G Sánchez-LozadaJaime Herrera-Acosta
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Apr 19, 2003·Archives of Gynecology and Obstetrics·Kai J BuhlingJoachim W Dudenhausen
Jul 16, 2003·Epidemiology·Tara E O'BrienWee-Shian Chan
Nov 25, 2003·American Journal of Obstetrics and Gynecology·Margaret P RaymanChristopher W G Redman

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Citations

Jul 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eamonn BreslinSiobhan Quenby
Oct 20, 2010·Nature Reviews. Nephrology·Annabel C Martin, Mark A Brown
Feb 7, 2009·Reproductive Sciences·Shannon A BainbridgeJames M Roberts
Jul 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aleksandra Novakov MikicZoran Stosic
Dec 6, 2006·The Urologic Clinics of North America·Arundhathi Jeyabalan, Kristine Y Lain
Aug 1, 2013·The Cochrane Database of Systematic Reviews·Lelia DuleyLeanne Jones
Apr 28, 2020·The Journal of Clinical Hypertension·Ioannis BellosGeorgios Daskalakis
Sep 3, 2020·The Cochrane Database of Systematic Reviews·Pedro Henrique França Gois, Edison Regio de Moraes Souza
Apr 14, 2017·The Cochrane Database of Systematic Reviews·Pedro Henrique França Gois, Edison Regio de Moraes Souza

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