Hyperuricemia and dementia - a case-control study

BMC Neurology
Bettina EngelBritta Haenisch

Abstract

There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) levels or hyperuricemia and dementia remains elusive. Most studies focused on the disease or SUA levels. Effects of anti-hyperuricemic treatment have not been considered yet. This study investigated the association between hyperuricemia and dementia taking into account anti-hyperuricemic treatment. We used longitudinal German public health insurance data and analyzed the association between hyperuricemia with and without different treatment options and dementia in a case-control design. Applying logistic regression the analysis was adjusted for several potential confounders including various comorbidities and polypharmacy. We identified 27,528 cases and 110,112 matched controls of which 22% had a diagnosis of hyperuricemia or gout and 17% received anti-hyperuricemic drugs. For patients with a diagnosis of hyperuricemia we found a slightly reduced risk for dementia (adjusted odds ratio [OR] 0.94, 95% confidence interval [CI] 0.89 to 0.98). The risk reduction was more pronounced for patients treated with anti-hyperur...Continue Reading

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Citations

Dec 11, 2019·Scientific Reports·Anatoly L Mayburd, Ancha Baranova
Oct 4, 2020·International Journal of Molecular Sciences·Yoichi ChibaMasaki Ueno
Feb 18, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kyung Hyun MinKyung Eun Lee
Oct 8, 2020·Arthritis Care & Research·Kristin M D'SilvaHyon K Choi
Jul 25, 2021·Journal of Clinical Medicine·Florence LaiHerminia Diana Rosas

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