Hyperuricemia and incident heart failure.

Circulation. Heart Failure
Eswar Krishnan

Abstract

Hyperuricemia, a known correlate of oxidative stress, is a marker for adverse prognosis among individuals with heart failure. However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied. We prospectively analyzed the relationship between serum uric acid concentration at baseline and subsequent heart failure among the participants of the Framingham Offspring cohort (n=4912; mean baseline age, 36 years; 52% women). By using Cox regressions, we calculated the risk of heart failure with increasing serum uric acid after adjusting for sex, age, smoking, body mass index, renal dysfunction, diuretics, systolic blood pressure, valvular heart disease, diabetes, alcohol, and use of antihypertensive medications. The incidence rates of heart failure were approximately 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). The adjusted hazard ratio for the highest quartile of serum uric acid compared with the lowest was 2.1 (1.04 to 4.22). The relationship between hyperuricemia and heart failure was found in participants without metabolic syndrome and other subgroups as well....Continue Reading

References

Jan 1, 1979·Postgraduate Medical Journal·R D ThomasD B Morgan
Jan 1, 1988·Journal of Clinical Epidemiology·R D AbbottW P Castelli
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
May 22, 1996·JAMA : the Journal of the American Medical Association·D LevyK K Ho
Jan 14, 1999·European Heart Journal·F LeyvaA J Coats
May 8, 1999·The European Respiratory Journal·M M HoeperH Fabel
May 22, 1963·Annals of the New York Academy of Sciences·T R DAWBERL P LYELL
Feb 12, 2004·Kidney International·Aud HøieggenUNKNOWN LIFE Study Group
Aug 28, 2004·The Medical Clinics of North America·Satish KenchaiahRamachandran S Vasan
Jan 22, 2005·Seminars in Nephrology·John Kanellis, Duk-Hee Kang
Jan 22, 2005·Seminars in Nephrology·Wolfram Doehner, Stefan D Anker
Mar 31, 2005·American Journal of Hypertension·Richard J JohnsonJaime Herrera-Acosta
Aug 9, 2005·The American Journal of Medicine·Joshua F BakerH Ralph Schumacher
Aug 16, 2005·The American Journal of Cardiology·Sunao KojimaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 14, 2006·European Heart Journal·Carmelinda RuggieroLuigi Ferrucci
Jul 28, 2006·Arthritis and Rheumatism·Eswar KrishnanH Ralph Schumacher
Sep 6, 2006·Journal of Cardiac Failure·Horacio E CingolaniNéstor G Pérez
Oct 27, 2006·European Journal of Heart Failure·Domingo A Pascual-FigalMariano Valdes
Dec 28, 2006·Hypertension·Eswar KrishnanLewis Kuller
Jan 3, 2007·American Journal of Hypertension·Thais de A CoutinhoIftikhar J Kullo
Apr 17, 2007·European Journal of Heart Failure·Wolfram DoehnerStefan D Anker
Nov 28, 2007·Clinical Chemistry·Alexander StrasakUNKNOWN VHM&PP Study Group
Apr 30, 2008·Rheumatology·Z Avram, E Krishnan
May 28, 2008·Archives of Internal Medicine·Eswar KrishnanUNKNOWN MRFIT Research Group
Jun 19, 2008·European Journal of Heart Failure·Hernan AlcainoSergio Lavandero
Jul 22, 2008·Current Rheumatology Reports·Eswar Krishnan
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson

❮ Previous
Next ❯

Citations

May 7, 2011·International Urology and Nephrology·Markus RiegerspergerDavid Goldsmith
Dec 21, 2013·Current Rheumatology Reports·Melissa L FernandezGary K Shooter
Jul 23, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sheena N RamasamyRichard O Day
Jul 26, 2012·Journal of Hypertension·Anna GlubaMaciej Banach
May 16, 2012·Heart Failure Reviews·Marc Kaufman, Maya Guglin
Nov 30, 2012·Clinical and Experimental Nephrology·Hiroyuki TerawakiSadayoshi Ito
Feb 19, 2016·Journal of Atherosclerosis and Thrombosis·Wen ZhangUNKNOWN EPOCH-JAPAN GROUP
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Sebastian E SattuiAngelo L Gaffo
Jan 30, 2016·Journal of the American College of Cardiology·Tanya KeenanDanish Saleheen
Nov 26, 2013·Rheumatic Diseases Clinics of North America·Vidula Bhole, Eswar Krishnan
Jun 2, 2011·Free Radical Biology & Medicine·Koichi Sugamura, John F Keaney
Mar 7, 2013·Arthritis Care & Research·Gim Gee TengWoon-Puay Koh
May 17, 2012·Congestive Heart Failure·Eswar KrishnanBhavik J Pandya
Aug 13, 2013·European Journal of Heart Failure·He HuangJi Wang
Apr 23, 2014·European Journal of Clinical Investigation·Claudio BorghiArrigo F G Cicero
Oct 27, 2015·BioMed Research International·Noor Mohammad NooriAlireza Jahangirifard
Jun 4, 2015·Environmental Health and Preventive Medicine·Kentaro TanakaKazuo Hayakawa
Dec 3, 2016·Journal of Atherosclerosis and Thrombosis·Wen ZhangUNKNOWN EPOCH-JAPAN GROUP
Jun 9, 2015·British Journal of Hospital Medicine·David WarrinerPatricia Lawford
Dec 30, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Angelo L Gaffo, Kenneth G Saag
Apr 10, 2014·Menopause : the Journal of the North American Menopause Society·Eswar KrishnanLinjun Chen
Aug 17, 2020·Expert Opinion on Therapeutic Patents·Jatinder Vir SinghSahil Sharma
Jan 30, 2016·Terapevticheskiĭ arkhiv·A S SkotnikovM A Khamurzova
Mar 12, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alessandro MalobertiUNKNOWN Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
Oct 26, 2018·Circulation Research·Nasrien E Ibrahim, James L Januzzi
Jun 19, 2020·Clinical Hypertension·Seung Jae LeeKi-Chul Sung
Jun 12, 2019·Heart Failure Reviews·Michael SarheneFan Guanwei
Jan 7, 2019·BMC Cardiovascular Disorders·Viera StubnovaBård Waldum-Grevbo
Jul 23, 2020·Journal of Hypertension·Maria L MuiesanUNKNOWN from the Working Group on Uric Acid, Cardiovascular Risk of the Italian Society of Hypertension
Feb 4, 2021·Heart Failure Reviews·Maja NikolicVladimir Jakovljevic
Jun 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·O S MichaelL A Olatunji
Aug 3, 2020·European Journal of Internal Medicine·Claudio BorghiKonstantinos P Tsioufis
Jan 4, 2021·Journal of cardiology·Yuichi SaitoYoshio Kobayashi
Jun 3, 2021·International Journal of Molecular Sciences·Giuseppe PalmieroFerdinando Carlo Sasso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.