Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
Alessandro MalobertiWorking Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

Abstract

The latest European Guidelines of Arterial Hypertension have officially introduced uric acid evaluation among the cardiovascular risk factors that should be evaluated in order to stratify patient's risk. In fact, it has been extensively evaluated and demonstrated to be an independent predictor not only of all-cause and cardiovascular mortality, but also of myocardial infraction, stroke and heart failure. Despite the large number of studies on this topic, an important open question that still need to be answered is the identification of a cardiovascular uric acid cut-off value. The actual hyperuricemia cut-off (> 6 mg/dL in women and 7 mg/dL in men) is principally based on the saturation point of uric acid but previous evidence suggests that the negative impact of cardiovascular system could occur also at lower levels. In this context, the Working Group on uric acid and CV risk of the Italian Society of Hypertension has designed the Uric acid Right for heArt Health project. The primary objective of this project is to define the level of uricemia above which the independent risk of CV disease may increase in a significantly manner. In this review we will summarize the first results obtained and describe the further planned analysis.

References

Jun 1, 1976·Kidney International·H W SpencerR R Robinson
Aug 16, 2005·The American Journal of Cardiology·Sunao KojimaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Dec 27, 2005·Current Pharmaceutical Design·G K GlantzounisD A Galaris
May 6, 2006·Stroke; a Journal of Cerebral Circulation·Michiel J BosMonique M B Breteler
Sep 12, 2008·American Journal of Physiology. Cell Physiology·Sergey ZharikovJawaharlal Patel
Feb 10, 2009·International Journal of Cardiology·O James EkundayoAli Ahmed
Nov 19, 2009·Circulation. Heart Failure·Eswar Krishnan
Jan 29, 2011·Congestive Heart Failure·Leonardo TamarizJoshua Hare
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Michelle P KaoAllan D Struthers
Jan 31, 2013·Metabolic Syndrome and Related Disorders·Kristy OsgoodMarie Thearle
Aug 13, 2013·European Journal of Heart Failure·He HuangJi Wang
Oct 9, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G NdrepepaR Schmidt
Jan 28, 2014·International Heart Journal·Ayako YoshimuraTsutomu Imaizumi
Feb 1, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Francesca ViazziRoberto Pontremoli
Mar 29, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G MulèS Cottone
Aug 20, 2014·Hypertension·Catherine J BeattieJesse Dawson
Sep 18, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shasha YuYingxian Sun
Nov 25, 2017·The Journal of Clinical Hypertension·Alessandro MalobertiCristina Giannattasio
Feb 11, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Giovambattista DesideriUNKNOWN Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension
Jun 15, 2018·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C MancusiG de Simone
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Sep 25, 2018·Expert Opinion on Emerging Drugs·Lisa K StampJasvinder A Singh
Mar 8, 2019·European Heart Journal·Sunao KojimaHisao Ogawa
Apr 11, 2019·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Francesco Antonini-CanterinBogdan A Popescu
Jun 22, 2019·The Journal of Clinical Hypertension·Alessandro MalobertiCristina Giannattasio

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Citations

Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Yuying WangYingli Lu
Mar 25, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Andrea Semplicini
Jul 28, 2020·European Journal of Internal Medicine·Marco CentolaStefano Carugo
Oct 1, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Alessandro MalobertiCristina Giannattasio
Jan 28, 2021·Journal of Clinical Medicine·Federica PianiClaudio Borghi
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Kazuya HondaKenji Kamiya
Sep 26, 2020·Renal Failure·Tadej PetreskiSebastjan Bevc
Feb 25, 2021·Risk Management and Healthcare Policy·Weiqi LiuZhongxing Xie
Feb 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Cheng-Wei LiuJuey-Jen Hwang
Apr 4, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Alessandro MalobertiCristina Giannattasio
Apr 28, 2021·Angiology·Atalay DemirayMehmet Kanbay
Apr 29, 2021·International Journal of General Medicine·Meseret Derbew MollaZeleke Geto
May 18, 2021·Journal of the American Heart Association·Massimo R MannarinoUNKNOWN IMPROVE study group †
May 25, 2021·Therapeutic Advances in Musculoskeletal Disease·Fengjing LiuHaibing Chen
Jun 12, 2021·Journal of Comparative Effectiveness Research·Milan HromadkaOtto Mayer

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