Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

BMC Cardiovascular Disorders
Sai LvXiaoli Liu

Abstract

Coronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is associated with CAD; however, the interaction effect between HUA and smoking on CAD is uncertain. Therefore, this study was designed to determine the relationship and interactive effects of HUA and smoking on the risk of CAD in young adults ≤ 35 years of age. In this observational study we consecutively included adults (18-35 years of age) with suspected CAD who underwent coronary angiography for the first time in our institution from January 2005 to December 2015. Patients with stenosis affecting ≥50% of the luminal diameter and acute myocardial infarction were considered to have CAD. A serum uric acid (SUA) level ≥ 7.0 mg / dl (420 mmol / L) in males and ≥ 6.0 mg / dl (357 mmol / L) in females was defined as hyperuricemia. We tested for an interaction between HUA and cigarrete smoking on CAD. The relationship between HUA, cigarrete smoking, and CAD was assessed by multivariate logistic regression analysis. A total of 1113 participants were included in this study; 771 participants were confirmed to have CAD. HUA was pres...Continue Reading

References

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Citations

May 1, 2019·BMC Public Health·Haleh AyatollahiMasoud Salehi
Jun 14, 2020·BMC Cardiovascular Disorders·Ruifang LiuTongku Liu

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

R
EmpowerStats

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