Hyperuricemia and the echocardiographic measures of myocardial dysfunction

Congestive Heart Failure
Eswar KrishnanBhavik J Pandya

Abstract

Few studies have investigated the association between hyperuricemia and subclinical myocardial dysfunction. The authors analyzed the relationship between serum uric acid and subclinical markers of heart failure in participants in the Framingham Offspring Cohort (N=2169, mean age 57.3 years, 55.4% women). Cardiac dysfunction was assessed through echocardiographic measurements of left ventricular (LV) mass and thickness, end-diastolic LV thickness, and LV fractional shortening at the sixth visit, approximately 24 years after study onset. Participants in the highest serum uric acid quartile (≥ 6.2 mg/dL serum uric acid) had a significantly greater frequency of echocardiographic abnormalities compared with those in the lowest quartile (<4.3 mg/dL). Those in the highest quartile had multivariable-adjusted odds ratios of 9.013 (95% confidence interval, 2.051-39.604) for abnormal LV ejection fraction and 4.584 (95% confidence interval, 1.951-10.768) for LV systolic dysfunction compared with those in the lowest quartile. Hyperuricemia in young adults can be a marker for subsequent heart failure.

Associated Clinical Trials

References

Jan 1, 1979·Postgraduate Medical Journal·R D ThomasD B Morgan
Sep 1, 1979·American Journal of Epidemiology·W B KannelW P Castelli
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jan 1, 1988·Journal of Clinical Epidemiology·R D AbbottW P Castelli
Jan 14, 1999·European Heart Journal·F LeyvaA J Coats
May 8, 1999·The European Respiratory Journal·M M HoeperH Fabel
Jul 10, 2002·Circulation·Colin A J FarquharsonAllan D Struthers
Sep 7, 2002·JAMA : the Journal of the American Medical Association·Ramachandran S VasanDaniel Levy
Dec 11, 2002·Circulation·Donald M Lloyd-JonesUNKNOWN Framingham Heart Study
Aug 13, 2003·Circulation·Thomas J WangRamachandran S Vasan
Aug 16, 2005·The American Journal of Cardiology·Sunao KojimaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Jul 14, 2006·The New England Journal of Medicine·Douglas S LeeRamachandran S Vasan
Sep 6, 2006·Journal of Cardiac Failure·Horacio E CingolaniNéstor G Pérez
Oct 27, 2006·European Journal of Heart Failure·Domingo A Pascual-FigalMariano Valdes
Apr 17, 2007·European Journal of Heart Failure·Wolfram DoehnerStefan D Anker
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators
Feb 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu MitsuhashiKoji Tamakoshi
Mar 20, 2009·The New England Journal of Medicine·Kirsten Bibbins-DomingoStephen B Hulley
May 16, 2009·Current Hypertension Reports·Brett R Cowan, Alistair A Young
Aug 21, 2009·International Journal of Clinical Practice·L WeiT M MacDonald
Nov 19, 2009·Circulation. Heart Failure·Eswar Krishnan
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 24, 2010·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 15, 2010·Lancet·Renjith Antony, Henry J Dargie
Aug 11, 2010·Archives of Internal Medicine·George ThanassoulisLouise Pilote

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Citations

Apr 22, 2010·Diabetology & Metabolic Syndrome·Anthonia O Ogbera, Alfred O Azenabor
Jul 3, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lauren D ReschkeTammy M Brady
Apr 23, 2014·European Journal of Clinical Investigation·Claudio BorghiArrigo F G Cicero
Nov 17, 2015·Arthritis Research & Therapy·Jing-Chi LinKuo-Li Pan

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