Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: a systematic review and meta-analysis

Clinical Chemistry and Laboratory Medicine : CCLM
Federica BragaMauro Panteghini

Abstract

Previous meta-analyses reported no significant or weak association between hyperuricemia (HU) and coronary heart disease (CHD). We updated the literature search, systematically reviewing retrieved papers. The peer-reviewed literature published from 1965 to December 2014 was searched using Medline and Embase. We included prospective cohort studies involving adults (sample size ≥100) with no cardiovascular disease (CVD) and a follow-up of at least 1 year. Studies were excluded if they considered as outcome the CVD incidence/mortality without separately reporting data on CHD, did not adjusted for major confounders and if the 95% confidence interval (CI) for risk ratio (RR) was not available. Relative risk or hazard ratio estimates, with the corresponding CIs, were obtained. For CHD incidence 12 populations were included (457,915 subjects [53.7% males]). For CHD mortality seven populations were included (237,433 subjects [66.3% males]). The overall combined RR were 1.206 (CI 1.066-1.364, p=0.003) for CHD incidence and 1.209 (CI 1.003-1.457, p=0.047) for CHD mortality, respectively. Subgroup analysis showed a marginal (incidence) and not significant (mortality) association between HU and CHD in men, but an increased risk for CHD inc...Continue Reading

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Citations

Jul 26, 2017·Transplantation·Krista L LentineAmit X Garg
Jul 23, 2016·International Journal of Environmental Research and Public Health·Zhao LiMaria Roselle Abraham
Sep 17, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Alessandro BattaggiaLuca Puccetti
Nov 16, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Federica BragaMauro Panteghini
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Software Mentioned

Comprehensive Meta - Analysis ( CMA )
MOOSE

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