Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Marc ParrishJames N Martin

Abstract

Hyperuricemia has received much attention and debate recently with regard to its utility as a marker for preeclampsia and as a predictor of adverse maternal-fetal outcome. This investigation was undertaken in patients with severe/superimposed preeclampsia to determine whether the maternal uric acid (UA) level at initial hospital admission is a useful predictor of subsequent adverse maternal and/or perinatal outcomes. Retrospective analysis of all patients diagnosed with severe preeclampsia, superimposed preeclampsia or HELLP syndrome during 2005 at the University of Mississippi Medical Center (UMMC). Clinical and laboratory data were collected, entered and stored electronically in a password protected, secure system. Adverse maternal outcomes occurred in 15.3% of 258 patients in the cohort. Mean UA concentration in the absence of adverse maternal outcomes was 342.6 ± 77.3 compared to 396.1 ± 117.2 μmol/l in pregnancies with complications (p<0.001). The positive likelihood ratio (LR) for adverse maternal outcome was 5.3 with UA ≥ 76.3 μmol/l and creatinine ≥ 1.0 mg/dl. LRs rose in association with other abnormal preeclampsia serum markers. Adverse perinatal outcomes occurred in 45.2% of births. The LRs for adverse perinatal outc...Continue Reading

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Citations

Aug 17, 2012·Expert Review of Cardiovascular Therapy·Gianni Bellomo
Nov 1, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Franziska Pettit, Mark A Brown
Apr 5, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Beth PaynePeter von Dadelszen
Jun 13, 2018·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Mohamed RezkHassan Badr
Jul 18, 2018·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Caroline C MarrsGayle Olson
Aug 31, 2011·Hypertension·Gianni BellomoPier Luca Narducci
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Oct 5, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xiaobo ZhaoTao Duan
Jul 12, 2018·Current Hypertension Reports·Olive P KhaliqThajasvarie Naicker
May 16, 2019·The Cochrane Database of Systematic Reviews·Alexander Ep HeazellClare Davenport

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