Hyperuricemia is associated with impaired intestinal permeability in mice

American Journal of Physiology. Gastrointestinal and Liver Physiology
Daxing XuShichao Xing

Abstract

Hyperuricemia is associated with many metabolic diseases. However, the underlying mechanism remains unknown. The gut microbiota has been demonstrated to play significant roles in the immunity and metabolism of the host. In the present study, we constructed a hyperuricemic mouse model to investigate whether the metabolic disorder caused by hyperuricemia is related to intestinal dysbiosis. A significantly increased intestinal permeability was detected in hyperuricemic mice. The difference in microflora between wild-type and hyperuricemic mice accompanies the translocation of gut microbiota to the extraintestinal tissues. Such a process is followed by an increase in innate immune system activation. We observed increased LPS and TNF-α levels in the hyperuricemic mice, indicating that hyperuricemic mice were in a state of low-grade systemic inflammation. In addition, hyperuricemic mice presented early injury of parenteral tissue and disordered lipid metabolism. These findings suggest that intestinal dysbiosis due to an impaired intestinal barrier may be the key cause of metabolic disorders in hyperuricemic mice. Our findings should aid in paving a new way of preventing and treating hyperuricemia and its complications.NEW & NOTEWORTH...Continue Reading

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Citations

Feb 28, 2020·Chinese Medical Journal·Peng-Xu WangHui-Juan Yuan
Jul 28, 2020·International Journal of Molecular Sciences·Shaoshi WenTao Wang
Dec 2, 2020·Microorganisms·Ryota IkeeSawako Fukazawa
Jan 23, 2021·Critical Reviews in Food Science and Nutrition·Jing WangFengqin Feng
Sep 23, 2021·Journal of Agricultural and Food Chemistry·Xiaoqing LiChao Zhao

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Methods Mentioned

BETA
Genotyping
PCR
enzyme-linked immunosorbent assay
ELISA
IECs

Software Mentioned

DEGseq
Quantitative Insights into Microbial Ecology ( QIIME )
PossionDis
cluster

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