Hyperuricemia is associated with progression of IgA nephropathy

International Urology and Nephrology
Ali BakanMehmet Kanbay

Abstract

IgA nephropathy (IgAN) is one of the world's most common glomerular diseases. Hyperuricemia was recently defined as risk factor for chronic kidney disease. We aimed to investigate the impact of baseline serum uric acid levels on progression of IgAN. A total of 93 patients with IgAN were screened. Demographic information and biochemical data were recorded. eGFR (using the CKD-EPI = Chronic Kidney Disease Epidemiology Collaboration formula) was used as renal function marker. Baseline and sixth month eGFR values were calculated. Progression of renal disease was defined as the difference between baseline eGFR and sixth month eGFR (delta eGFR). Mean age of the patients was 40 ± 11 years (60% were males). Baseline mean eGFR was 77.9 ± 30.2 mL/min, and baseline mean serum uric acid was 5.65 ± 1.68 mg/dL. Importantly, baseline serum uric acid levels were found to be associated with the change in eGFR (r = 0.252, p = 0.01). In multivariate analysis (adjusted R(2) = 0.171, p = 0.031), adjusting for age, gender, baseline eGFR, blood pressure, baseline albumin concentration and ACEI and/or ARB use revealed that the baseline serum uric acid levels significantly predicted the change in eGFR. Baseline serum uric acid concentration is directly...Continue Reading

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Citations

Jun 25, 2016·Clinical and Experimental Nephrology·Takanori KumagaiShunya Uchida
Jan 16, 2020·Journal of Clinical Medicine·Tae Ryom OhEun Hui Bae
Mar 18, 2020·Journal of Clinical Medicine·Tae Ryom OhSeong Kwon Ma
Jul 15, 2020·International Urology and Nephrology·Łukasz KuźmaSławomir Dobrzycki
Oct 31, 2020·Frontiers in Immunology·Haresh SelvaskandanJonathan Barratt
Jul 11, 2020·Kidney International·Claudio PonticelliGabriella Moroni
May 14, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ron Hogg

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