Abstract
Serum uric acid (UA, mg/dl) levels associate with the pathophysiology and prognosis in patients with chronic heart failure. To clarify the clinical significance of hyperuricemia (HUA, UA>7.0) in Fontan patients. We prospectively measured UA in 197 child and 102 adult Fontan patients and compared the results with the clinical variables, including hemodynamics, exercise capacity, and plasma levels of norepinephrine (NE) and brain natriuretic peptide, and unscheduled hospitalization (USH), including all-cause mortality. The mean UA was 5.8 ± 1.7 and 66 patients (22%, 34% in the adults) showed HUA. HUA was associated with lower peak oxygen uptake only in adults (r = -0.35, p < 0.0001). In children the use of diuretics, central venous pressure, liver enzymes, NE, and plasma creatinine (Cr) independently associated with UA. Of those, in addition to hypoxia, the use of diuretics and Cr independently predicted HUA (p < 0.05-0.001). In adults, hypoxia, plasma levels of sodium and Cr independently determined UA. Of those, hypoxia and hyponatremia independently predicted HUA (p < 0.05-0.001). During a follow-up of 49 ± 27 months, 67 USH, including 17 deaths, occurred. In all patients, on univariate analysis, HUA predicted mortality (hazar...Continue Reading
References
Jan 1, 1990·Drugs·S LjungmanR J Cody
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Mar 1, 1986·Circulation·E A RossM M Canobbio
Feb 1, 1968·Analytical Biochemistry·G F Domagk, H H Schlicke
Nov 20, 1981·Journal of Chromatography·K Mori
Jan 1, 1996·Pediatric Cardiology·H OhuchiT Kamiya
Jun 1, 1997·Cardiovascular Research·G AmbrosioP Golino
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Vásquez-VivarK A Pritchard
Dec 22, 1999·Archives of Biochemistry and Biophysics·C X SantosO Augusto
Jun 22, 2000·Heart·H OyaK Miyatake
Apr 17, 2001·Hypertension·J G WangL Liu
Sep 5, 2002·Free Radical Biology & Medicine·Roger Harrison
Dec 11, 2002·Circulation·Ulf LandmesserHelmut Drexler
Dec 25, 2003·The Journal of Physiology·Cristine E Berry, Joshua M Hare
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Concetta PronteraAldo Clerico
Apr 27, 2004·Cardiovascular Drugs and Therapy·Ariel J Reyes
May 12, 2004·Pediatric Cardiology·H OhuchiS Echigo
Mar 23, 2005·Circulation·Shintaro KinugawaThomas H Hintze
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Apr 19, 2006·Circulation·Jeong-a KimMichael J Quon
Jul 26, 2006·The Annals of Thoracic Surgery·Adam M OstrowJack Rychik
Jul 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi SakaiMinoru Horie
Oct 4, 2006·Hypertension·Irving H Zucker
Oct 27, 2006·Nucleosides, Nucleotides & Nucleic Acids·Y MoriwakiT Yamamoto
May 2, 2007·Circulation·Earl S FordHyon K Choi
Jul 24, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Pasquale Strazzullo, Juan Garcia Puig
Dec 12, 2007·Circulation·Paul KhairyMichael J Landzberg
Mar 23, 2011·Congenital Heart Disease·Hideo OhuchiOsamu Yamada
Apr 27, 2012·Pediatric Cardiology·Jack RychikRebecca G Wells
Jul 23, 2013·International Journal of Cardiology·Tze-Fan ChaoShih-Ann Chen
Mar 22, 2014·International Journal of Cardiology·Hideo OhuchiOsamu Yamada
Apr 29, 2014·Biochemical and Biophysical Research Communications·Yuzhang ZhuJidong Cheng