Hypervalent Iodine(III) in Direct Oxidative Amination of Arenes with Heteroaromatic Amines

Organic Letters
Srimanta MannaOleg N Chupakhin

Abstract

A novel, mild, and practical method of amination of simple nonfunctionalized arenes under metal free conditions has been developed. The approach allows coupling of electron-rich arenes with amino derivatives of electron-deficient heterocycles providing rapid access to scaffolds of bioactive compounds and is based on the application of the hypervalent iodine(III) reagent as an oxidant. Regioselective functionalization of C-H bonds of arenes by the formation of C-N bonds under organocatalytic conditions was demonstrated.

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