Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents

European Journal of Medicinal Chemistry
Om PrakashK R Aneja

Abstract

A series of novel 2,5-disubstituted 1,3,4-oxadiazoles 4 have been conveniently synthesized by oxidative cyclization of pyrazolylaldehyde N-acylhydrazones 3 promoted by iodobenzene diacetate under mild conditions (11 examples, up to 92% isolated yields). All the eleven compounds were tested in vitro for their antibacterial activity against gram-positive bacteria namely, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their inhibitory action against two strains of fungus.

Citations

Jul 10, 2013·European Journal of Medicinal Chemistry·N C DesaiAmit Trivedi
Mar 1, 2012·Organic and Medicinal Chemistry Letters·Deepak K AnejaOm Prakash
Jan 1, 2013·International Journal of Medicinal Chemistry·Basavapatna N Prasanna KumarKikkeri P Harish
Sep 21, 2013·ISRN Organic Chemistry·Kikkeri N Mohana, Chikkur B Pradeep Kumar
Apr 25, 2017·Acta Crystallographica. Section E, Crystallographic Communications·Huma BanoSammer Yousuf
Mar 8, 2017·Chemical Biology & Drug Design·Yasodakrishna SajjaJagadeesh Babu Nanubolu
May 22, 2019·Acta Crystallographica. Section E, Crystallographic Communications·Lamya H Al-WahaibiOlivier Blacque
Aug 14, 2020·Chemistry : a European Journal·Luke GreenCraig Jamieson
Dec 29, 2020·Bioorganic & Medicinal Chemistry·Valentin KarabelyovViolina T Angelova
Jan 25, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Esra BağdaEfkan Bağda

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