PMID: 8582370Sep 1, 1995Paper

Hypervariable genomic variation to reconstruct the natural history of populations: lessons from the big cats

Electrophoresis
Marilyn Menotti-Raymond, S J O'Brien

Abstract

The extent and nature of variation in hypervariable regions DNA have been used in the past as a means to infer the natural histories of populations. We review the interpretation of the extent of genetic diversity for minisatellite DNA in the cheetah to estimate the timing of a population bottleneck in the species and the potential application of a second class of hypervariable DNA, microsatellite DNA, as a molecular tool to examine the natural histories of felid populations. A calibration curve relating the degree of allele fragment sharing in individuals to relatedness in a captive pedigree of cheetahs is presented. This measurement has important applications for management of potential matings in captive management situations.

References

Oct 29, 1992·Nature·J WeissenbachM Lathrop
Sep 1, 1991·The Journal of Heredity·D A GilbertS J O'Brien
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N Yuhki, S J O'Brien
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H K ReeveC F Aquadro
Jan 1, 1987·Animal Genetics·A J Jeffreys, D B Morton
Mar 22, 1985·Science·S J O'BrienD E Wildt
May 26, 1988·Nature·A R Hoelzel, W Amos
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S J O'BrienR E Leakey
Jul 1, 1964·Journal of Theoretical Biology·W D Hamilton
Mar 31, 1994·Nature·A M BowcockL L Cavalli-Sforza
Jul 1, 1995·The Journal of Heredity·M A Menotti-Raymond, S J O'Brien
Jan 1, 1994·Annual Review of Genetics·S J O'Brien
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J O'Brien
Dec 1, 1993·Current Opinion in Genetics & Development·M W Bruford, R K Wayne
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M Menotti-Raymond, S J O'Brien
Jul 29, 1983·Science·S J O'brienM Bush
Oct 1, 1988·Trends in Ecology & Evolution·S J O'Brien, J F Evermann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.