Hypervariable prophage WO sequences describe an unexpected high number of Wolbachia variants in the mosquito Culex pipiens.

Proceedings. Biological Sciences
Olivier DuronMylène Weill

Abstract

Wolbachia are maternally inherited endosymbiotic bacteria that infect many arthropod species and may induce cytoplasmic incompatibility (CI) resulting in abortive embryonic development. Among all the described host species, mosquitoes of the Culex pipiens complex display the highest variability of CI crossing types. Paradoxically, searches for polymorphism in Wolbachia infecting strains and field populations hitherto failed or produced very few markers. Here, we show that an abundant source of the long-sought polymorphism lies in WO prophage sequences present in multiple copies dispersed in the genome of Wolbachia infecting C. pipiens (wPip). We identified up to 66 different Wolbachia variants in C. pipiens strains and field populations and no occurrence of superinfection was observed. At least 49 different Wolbachia occurred in Southern Europe C. pipiens populations, and up to 10 different Wolbachia were even detected in a single population. This is in sharp contrast with North African and Cretan samples, which exhibited only six variants. The WO polymorphism appeared stable over time, and was exclusively transferred maternally. Interestingly, we found that the CI pattern previously described correlates with the variability of...Continue Reading

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Citations

Apr 26, 2011·Molecular Biology and Evolution·Célestine M AtyameOlivier Duron
Jun 14, 2006·Proceedings. Biological Sciences·Jason L RasgonThomas W Scott
Aug 21, 2008·Annual Review of Genetics·Laura R SerbusWilliam Sullivan
Mar 26, 2009·BMC Evolutionary Biology·Sylvain CharlatGregory D D Hurst
May 20, 2006·PLoS Pathogens·Seth R BordensteinJennifer J Wernegreen
Jan 20, 2010·Trends in Microbiology·Bethany N Kent, Seth R Bordenstein
Jan 10, 2009·Insect Molecular Biology·P TortosaM Weill
Jun 17, 2011·Molecular Ecology Resources·Michael Petridis, Dimitrios Chatzidimitriou
Nov 17, 2009·Journal of Evolutionary Biology·A DuplouyS Charlat
Aug 27, 2014·Molecular Microbiology·Gerald D BaldridgeAnn M Fallon
Nov 21, 2013·Acta Tropica·Kostas BourtzisJeremie R L Gilles
Jan 20, 2018·Genome Biology and Evolution·Amelia R I LindseyIrene L G Newton
Aug 17, 2006·Molecular Ecology·Olivier DuronMylène Weill

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