Hyperventilation and cerebrospinal fluid acidosis caused by topiramate

The Annals of Pharmacotherapy
Ambroise MontcriolBruno Palmier

Abstract

To report a case of hyperventilation caused by topiramate therapy and propose a pathophysiologic mechanism for this disorder. A 52-year-old woman with refractory seizure disorder was admitted to the burn care unit with burns over 10% of her body. Her seizure medications, unchanged and well tolerated for several months, included carbamazepine 1200 mg, lamotrigine 500 mg, phenobarbital 80 mg, and topiramate 150 mg per day. During hospitalization, despite a relatively normal arterial pH, the woman developed persistent hyperventilation, with respiratory rates up to 50 breaths/min. Alkalinization did not reduce the hyperventilation. Thoracic contrast-enhanced computed tomographic scan ruled out pulmonary embolism and persistent pneumonia. Salicylate and biguanide screening were negative; results of repeated thyroid and liver function tests were normal. Cerebral magnetic resonance imaging excluded a cerebral pathology. After cerebrospinal fluid (CSF) analysis showed acidosis (pH 7.14), topiramate was withdrawn and the patient's general condition rapidly improved. Forty-eight hours later, the CSF pH had increased to 7.26. The woman was discharged from the burn care unit on the 42nd hospital day. Hyperchloremic normal anion gap metabol...Continue Reading

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Citations

Mar 2, 2010·Medicina clínica·Silvia Franco Hidalgo, José María Prieto de Paula
Nov 14, 2013·British Journal of Clinical Pharmacology·Valentina G Dell'OrtoSebastiano A G Lava

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