PMID: 9192223Jun 1, 1997Paper

Hyperviscosity and microproteinuria in central obesity: relevance to cardiovascular risk

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
S B SolerteE Ferrari

Abstract

To investigate the role of blood rheology changes in the occurrence of glomerular proteinuria in obese patients with central fat distribution. Fifty-nine obese out-patients (31 with central and 28 with peripheral body fat distribution) and 24 healthy subjects. Blood and plasma viscosity (Rotational viscometer CV100 HAAKE), erythrocyte deformability (whole-blood filtration time), fibrinogen (nephelometry), urinary excretion rates of albumin, IgG, transferrin and IgA (nephelometry). Higher blood viscosity (at low and high shear-rates), plasma viscosity, fibrinogen, erythrocyte aggregability and lower erythrocyte deformability were found in patients with central obesity than in patients with peripheral obesity (P < 0.01) and in healthy subjects (P < 0.001). Furthermore an increased urinary excretion rate of albumin (P < 0.001), IgG (P < 0.001), transferrin (P < 0.01) and IgA (P < 0.05) was found in patients with central obesity than in the other two groups. Blood hyperviscosity (at shear-rate 1 s-1 and 1/200 ratio) significantly correlated with the amount of urinary excretion of proteins independently of the other clinical and metabolic variables. The data demonstrated haemorheologic disorders related to pathologic proteinuria in ...Continue Reading

Citations

Nov 25, 2004·Best Practice & Research. Clinical Gastroenterology·Xavier Formiguera, Ana Cantón
Jun 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H J MilionisM S Elisaf
Mar 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·A Erkin BozdemirOya Bayindir
Apr 26, 2007·Diabetes Care·Shalamar D SibleyUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Study
May 20, 2009·Clinical and Experimental Nephrology·Kazuko SuzukiIsao Kubota
Nov 22, 2008·Obesity·Eva SoláAntonio Hernández-Mijares
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shalamar D SibleyMichael W Steffes
Nov 17, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroko SugimoriHiroshi Inoue
May 31, 2003·Stroke; a Journal of Cerebral Circulation·Seung-Han SukUNKNOWN Northern Manhattan Stroke Study
Nov 23, 2011·Expert Review of Cardiovascular Therapy·Caroline RhéaumePaul Poirier

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