Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST)

Stroke; a Journal of Cerebral Circulation
F T AichnerK Zeiler

Abstract

Experimental studies suggest a beneficial effect of hemodilution on acute ischemic stroke. This was not proven by previous multicenter trials in the clinical setting. Various reasons have been suggested for the failure of these studies, which we attempted to consider in the Multicenter Austrian Hemodilution Stroke Trial (MAHST). MAHST is a randomized, double-blind, placebo-controlled study of hypervolemic hemodilution (HHD) within 6 hours of a clinically first ischemic stroke localized in the middle cerebral artery territory. The treatment consisted of 10% hydroxyethyl starch 200/0.5 (HES) and was tested against pure rehydration with Ringer's lactate over a period of 5 days. Our primary outcome measure was clinical improvement within 7 days as measured by the Graded Neurologic Scale (GNS). We performed an adaptive interim analysis to reevaluate the study goal after entering half of the projected number of patients (n = 200). At least 600 patients per group would have been required for significant results, and therefore we decided to terminate the trial. Ninety-eight patients received HHD and 102 patients placebo. The baseline characteristics were comparable between both groups. In the HHD group the absolute reduction of the hem...Continue Reading

References

Jun 1, 1976·Brain : a Journal of Neurology·W B MatthewsR C Greenhall
Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J ColeK Bradley
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D HeissK Wienhard
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·K Asplund
Sep 1, 1993·Surgical Neurology·M Ohtaki, B I Tranmer

❮ Previous
Next ❯

Citations

Jun 18, 2009·Intensive Care Medicine·Christiane Hartog, Konrad Reinhart
Apr 14, 2007·Journal of Neurology·Dong Hoon ShinOh Young Bang
Jan 1, 2003·Current Neurology and Neuroscience Reports·Thanh Nguyen, Walter J Koroshetz
Apr 23, 2003·Cardiology in Review·Jesse WeinbergerDawn Terashita
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Andreas H Kramer, David A Zygun
Nov 13, 2001·Journal of Neurosurgery·C StraussJ Romstöck
Dec 9, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A RösslerD Schneider
Sep 15, 2012·Emergency Medicine Clinics of North America·Joseph D BurnsChristina DeFusco
Sep 24, 2011·Lancet Neurology·Ashfaq ShuaibDavid S Liebeskind
Dec 3, 2009·Critical Care Nursing Clinics of North America·Anne W Wojner Alexandrov
Mar 1, 2008·Neuropharmacology·Myron D Ginsberg
Oct 28, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Paola PalazzoAndrei V Alexandrov
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·P Mitsias
Apr 11, 2000·Neurologic Clinics·K Becker
Feb 16, 2012·Clinical Neurology and Neurosurgery·Jon W SchrockKristin Drogell
Sep 4, 2015·The Cochrane Database of Systematic Reviews·Akila VisvanathanWilliam Whiteley
Aug 28, 2014·The Cochrane Database of Systematic Reviews·Timothy S Chang, Matthew B Jensen
Mar 13, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ayaka FujitaEiichi Tsuda
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.