Hyphenation of capillary electrophoresis to inductively coupled plasma mass spectrometry as an element-specific detection method for metal speciation

Journal of Chromatography. a
Bernhard Michalke, P Schramel

Abstract

A stepwise development for the use of capillary electrophoresis and inductively coupled plasma mass spectrometry (ICP-MS) for speciation investigations is presented. The high resolution power of CE is used for the separation of metal species, whereas ICP-MS is taken for element-specific detection with low detection limits. This contribution starts with an off-line combination of both instruments. Separation and identification of species in model solutions and real samples are shown by scanning UV detection at the CE unit with subsequent metal quantification in peak related fractions, applying electrothermal vaporization ICP-MS. Finally, first separations are demonstrated, using the on-line hyphenation with a laboratory-made nebulizer. Here, standard solutions are separated and monitored by UV and ICP-MS. Stability of electrical current during nebulization was checked and a possibly interfering suction flow was estimated. After optimization sufficient electropherograms were obtained. Advantages and problems are discussed for both modes.

Citations

Feb 10, 1998·Electrophoresis·M Macka, P R Haddad
Dec 31, 1998·Electrophoresis·S J KokU A Brinkman
Aug 14, 2003·Ecotoxicology and Environmental Safety·Joseph A Caruso, Maria Montes-Bayon
Jun 5, 2007·Journal of Chromatography. a·Jeroen E Sonke, Vincent J M Salters
Oct 27, 2004·Journal of Chromatography. a·Bernhard Michalke
Aug 7, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Victoria V VolchekSergey V Korenev
Jun 29, 1999·Analytical Chemistry·G Komaromy-Hiller

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