HYPO: A Database of Human Hypothetical Proteins

Protein and Peptide Letters
Vijayaraghava S SundararajanPrashanth Suravajhala

Abstract

There are genes whose function remains obscure as they may not have similarities to known regions in the genome. Such known 'unknown' genes constituting the Open Reading Frames (ORF) that remain in the epigenome are termed as orphan genes and the proteins encoded by them but having no experimental evidence of translation are termed as 'Hypothetical Proteins' (HPs). We have enhanced our former database of Hypothetical Proteins (HP) in human (HypoDB) with added annotation, application programming interfaces and descriptive features. The database hosts 1000+ manually curated records of the known 'unknown' regions in the human genome. The new updated version of HypoDB with functionalities (Blast, Match) is freely accessible at http://www.bioclues.org/hypo2. The total collection of HPs were checked using experimentally validated sets (from Swiss-Prot) or non-experimentally validated set (TrEMBL) or the complete set (UniProtKB). The database was designed with java at the core backend, integrated with databases, viz. EMBL, PIR, HPRD and those including descriptors for structural databases, interaction and association databases. The HypoDB constituted Application Programming Interfaces (API) for implicitly searching resources linking t...Continue Reading

Citations

Nov 21, 2020·Current Genomics·Girik MalikPrashanth Suravajhala

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