Hypoadiponectinemia is an independent risk factor for hypertension

Hypertension
Yoshio IwashimaToshio Ogihara

Abstract

Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2+/-0.2 microg/mL; NT: 6.1+/-0.2 microg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC:...Continue Reading

References

Feb 1, 1990·Diabetes Care·P D ReavenD K Browner
Apr 14, 1994·The New England Journal of Medicine·T F Lüscher
Mar 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S M Haffner
Nov 25, 1997·American Journal of Hypertension·J AgataK Shimamoto
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Oct 3, 1999·Progress in Cardiovascular Diseases·N MikhailM L Tuck
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F MassiéraM Teboul
Aug 7, 2002·Circulation·Joseph A Vita, John F Keaney
Jan 9, 2003·American Journal of Hypertension·Marcin AdamczakYuji Matsuzawa
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Masahiro KumadaUNKNOWN Osaka CAD Study Group. Coronary artery disease
Jul 16, 2003·Hypertension·Noriyuki OuchiYuji Matsuzawa
Aug 28, 2003·Diabetes·Robert S LindsayRobert L Hanson

❮ Previous
Next ❯

Citations

Feb 22, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Megan M Lo, Mark Mitsnefes
May 10, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Megan M LoMark M Mitsnefes
Aug 9, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kristina F MöllerDirk E Müller-Wiefel
Jun 19, 2007·Medical Molecular Morphology·Makoto NishidaIichiro Shimomura
Sep 14, 2011·Inflammation·Samir Ben AliNaziha Kaabachi
Oct 3, 2007·Internal and Emergency Medicine·R TarquiniG F Gensini
Aug 12, 2006·Current Atherosclerosis Reports·Tohru Funahashi, Yuji Matsuzawa
Feb 5, 2008·Current Atherosclerosis Reports·Yukihiro TakemuraNoriyuki Ouchi
Jan 3, 2006·Current Hypertension Reports·Gladys Velarde, Bradford C Berk
Apr 24, 2013·Journal of Cardiovascular Translational Research·Deepa M Gopal, Flora Sam
Jan 16, 2014·Indian Journal of Clinical Biochemistry : IJCB·Jai PrakashNeena Srivastava
Dec 5, 2006·Cardiovascular Research·Teresa A HopkinsKenneth Walsh
Dec 15, 2006·Cardiovascular Research·Naveen SharmaWilliam C Stanley
Jul 4, 2012·Pulmonary Pharmacology & Therapeutics·Benjamin D Medoff
Jun 23, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro KatsuyaToshio Ogihrara
Jul 29, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bai YoupengZhou Rong
Jan 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideo KohYonezo Hikita
Apr 6, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chun-Yen ChenMasafumi Kitakaze
Aug 24, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ana P C de FariaHeitor Moreno
Jul 25, 2008·Journal of Human Hypertension·E Teijeira-FernandezJ R Gonzalez-Juanatey
Jan 21, 2011·Journal of Human Hypertension·P J AveryB D Keavney
Mar 5, 2010·Journal of Human Hypertension·C ThomopoulosT Makris
Jan 5, 2006·Nature Clinical Practice. Cardiovascular Medicine·Yuji Matsuzawa
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Sep 6, 2012·The Journal of Biological Chemistry·Xiang ChengPeter Libby
May 14, 2008·Cardiovascular Research·Morris KarmazynAsad Zeidan
Apr 23, 2009·Cardiology in Review·Stephen J PetersonNader G Abraham
Feb 22, 2008·Journal of Cardiovascular Pharmacology·Ramesh NatarajanAlpha A Fowler
Sep 16, 2011·Clinical and Experimental Pharmacology & Physiology·Hui SuXin-Liang Ma
Apr 26, 2006·Diabetes, Obesity & Metabolism·J P WhiteheadJ B Prins
Feb 1, 2007·International Journal of Clinical Practice·E A Francischetti, V A Genelhu
Jul 27, 2010·Acta Physiologica·M VlasovaK H Herzig
Nov 26, 2009·Heart·Flora Sam, Kenneth Walsh
Jul 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Hwee TeohSubodh Verma
Mar 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Karen M O'SheaWilliam C Stanley
Jun 30, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ross SummerKenneth Walsh
Oct 21, 2011·Journal of Nutrition and Metabolism·Tiziana Di ChiaraGiuseppe Licata
Jan 19, 2012·Experimental Diabetes Research·N WolfsonM Shargorodsky
Aug 9, 2011·Journal of Nutrition and Metabolism·Andréa Name Colado SimãoIsaias Dichi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Arteriosclerosis, Thrombosis, and Vascular Biology
Masahiro KumadaOsaka CAD Study Group. Coronary artery disease
JAMA : the Journal of the American Medical Association
Tobias PischonEric B Rimm
© 2021 Meta ULC. All rights reserved