Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease

Heart
Aleksander KempnyKonstantinos Dimopoulos

Abstract

In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD) remains, however, unknown. Data on patients with ACHD who underwent blood testing in our centre within the last 14 years were collected. The relation between laboratory, clinical or demographic parameters at baseline and mortality was assessed using Cox proportional hazards regression analysis. A total of 2886 patients with ACHD were included. Mean age was 33.3 years (23.6-44.7) and 50.1% patients were men. Median plasma albumin concentration was 41.0 g/L (38.0-44.0), whereas hypoalbuminaemia (<35 g/L) was present in 13.9% of patients. The prevalence of hypoalbuminaemia was significantly higher in patients with great complexity ACHD (18.2%) compared with patients with moderate (11.3%) or simple ACHD lesions (12.1%, p<0.001). During a median follow-up of 5.7 years (3.3-9.6), 327 (11.3%) patients died. On univariable Cox regression analysis, hypoalbuminaemia was a strong predictor of outcome (HR 3.37, 95% CI 2.67 to 4.25, p<0.0001). On multivariable Cox regression, after adjusting for age, s...Continue Reading

References

Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·R H FeldtG K Danielson
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·L MertensM Gewillig
Jun 16, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P E Ballmer
Aug 23, 2003·Journal of the American College of Cardiology·Stéphane ArquèsGilbert Habib
Aug 23, 2003·Journal of the American College of Cardiology·Marvin A Konstam
Apr 20, 2004·Critical Care Medicine·Gregory J QuinlanTimothy W Evans
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J QuinlanTimothy W Evans
Jun 20, 2006·Journal of the American College of Cardiology·Hideaki SenzakiYuji Yokote
Nov 21, 2009·Journal of the American College of Cardiology·Konstantinos DimopoulosMichael A Gatzoulis
Mar 9, 2010·European Heart Journal·Carianne L VerheugtBarbara J M Mulder
Dec 15, 2010·American Heart Journal·Shanmugam UthamalingamJames L Januzzi
Mar 1, 2011·The Annals of Thoracic Surgery·Kim I de la CruzDanny Chu
Mar 30, 2011·Congenital Heart Disease·Fred M WuMichael G Earing
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Jun 16, 2012·International Journal of Medical Sciences·Qiang JiYunqing Mei
Apr 23, 2013·Biochimica Et Biophysica Acta·Chung-Eun Ha, Nadhipuram V Bhagavan
Jan 21, 2014·International Journal of Cardiology·Antonia C MoutafiConstantinos H Davos

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