Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Kotoe TakayoshiEishi Baba

Abstract

Venous thromboembolism (VTE) is highly associated with advanced gastric cancer (AGC) and is sometimes lethal. Predictors of VTE have not been identified, and the efficacy and safety of direct oral anticoagulants (DOACs) for AGC-associated VTE remain to be clarified. A total of 188 AGC patients who started chemotherapy during the period from January 2014 to December 2017 in our institutions were retrospectively examined for the incidence of VTE, risk factors for VTE, and the efficacy and safety of DOAC-based anticoagulant therapy for VTE. Thirty-four patients (18%) were diagnosed with VTE at the start or during the course of chemotherapy (VTE group). More VTE group patients had a history of abdominal surgery and had moderate-severe ascites (32% versus 17%, 32% versus 14%, respectively) than non-VTE group patients (NVTE group). The mean serum albumin concentrations in the VTE group were significantly lower than NVTE group (3.38 mg/dL vs 3.65 mg/dL, respectively). Multivariate analysis showed that hypoalbuminemia was significantly correlated with VTE (P = 0.012). In the VTE group, 29 patients (85%) received anticoagulant therapy, including 24 patients treated with DOACs. No lethal VTE was observed in any patients. Thirteen patient...Continue Reading

References

Aug 1, 1980·European Journal of Biochemistry·J MacloufB Samuelsson
Nov 7, 2000·British Journal of Anaesthesia·J P NicholsonG R Park
Dec 16, 2000·The New England Journal of Medicine·H T SørensenJ A Baron
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Jun 1, 2005·The Lancet Oncology·Paolo PrandoniAndrea Piccioli
Jan 4, 2006·Thrombosis Research·Tufia C Haddad, Edward W Greeno
Feb 27, 2007·Journal of Thrombosis and Haemostasis : JTH·A A KhoranaG H Lyman
Apr 15, 2010·Thrombosis and Haemostasis·Aaron R FolsomMary Cushman
Mar 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MandalàUNKNOWN ESMO Guidelines Working Group
Dec 16, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Myoung Joo KangYoon-Koo Kang
Mar 1, 2012·Haematologica·Cihan AyIngrid Pabinger
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Sep 27, 2015·Journal of Thrombosis and Haemostasis : JTH·G AgnelliT Yamabe
Sep 18, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jorge D RamosUNKNOWN Retrospective International Study of Cancers of the Urothelium (RISC) Investigators
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Geeta GyamlaniCsaba P Kovesdy
Dec 13, 2017·The New England Journal of Medicine·Gary E RaskobUNKNOWN Hokusai VTE Cancer Investigators

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Citations

Nov 20, 2019·European Journal of Epidemiology·Li-Zhen LiaoXin-Xue Liao
May 13, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Soghra Bagheri, Ali A Saboury
Mar 15, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Xing XinLing Feng
Sep 28, 2021·Frontiers in Oncology·Guang-Liang ChenWei-Jian Guo
Aug 14, 2021·Journal of Neurosurgery. Spine·Zach PenningtonDaniel M Sciubba

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