Hypoalgesia post-manipulative therapy: a review of a potential neurophysiological mechanism

Manual Therapy
A Wright

Abstract

This article provides a review of the available scientific evidence related to the structure and function of descending pain inhibitory systems projecting from the periaqueductal gray region to the spinal cord. The importance of these systems in the phenomenon of endogenous analgesia is discussed. The theory that the initial pain-relieving effect of manual therapy procedures may involve activation of these control systems is proposed and a series of hypotheses based on this theoretical concept are presented. Recent studies evaluating the effects of spinal mobilisation procedures are outlined and the outcomes of these studies are discussed in relation to theoretical role of descending pain inhibitory systems in manipulation-induced analgesia. Directions for further research in this area are considered.

Associated Clinical Trials

May 30, 2018·Jonathan Daniel Telles

Citations

Nov 2, 2012·The Journal of Manual & Manipulative Therapy·Carol A CourtneyMichael A O'Hearn
May 16, 2013·Chiropractic & Manual Therapies·Dennis Digiorgi
Mar 20, 2008·The Journal of Orthopaedic and Sports Physical Therapy·Paul E MintkenUNKNOWN American Academy of Orthopaedic Manual Physical Therapists
Apr 10, 2007·The Journal of Orthopaedic and Sports Physical Therapy·Toby HallKim Robinson
Mar 15, 2013·The Journal of Orthopaedic and Sports Physical Therapy·Jorge H VillafañeCésar Fernández-de-Las-Peñas
Jan 3, 2009·The Journal of Manual & Manipulative Therapy·Paul E MintkenUNKNOWN American Academy of Orthopaedic Manual Physical Therapists
Jun 3, 2008·The Journal of Orthopaedic and Sports Physical Therapy·Joel E BialoskyMark D Bishop
Aug 16, 2003·The Journal of Orthopaedic and Sports Physical Therapy·Michel W CoppietersKoen Janssens
Jul 6, 2014·Rehabilitation Research and Practice·Michel Silva ReisAudrey Borghi-Silva
Feb 20, 2016·Journal of Bodywork and Movement Therapies·Phuntsog AngmoMonalisa Pattnaik
Mar 9, 2010·Disability and Rehabilitation·Rotsalai KanlayanaphotpornRoongtiwa Vachalathiti
Mar 3, 2015·Acta Orthopaedica. Supplementum·Thomas Johan Kibsgård
Jul 11, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Daniel F MartinsAdair R S Santos
Mar 2, 2013·Journal of Chiropractic Medicine·Jorge H VillafañeOrazio L F Ragusa
Dec 16, 2011·Medical Hypotheses·Ashokan ArumugamGisela Sole
Feb 3, 2012·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Rogelio A CoronadoSteven Z George
Sep 29, 2011·Manual Therapy·Wouter Kristiaan Geerse
Sep 9, 2011·Journal of Manipulative and Physiological Therapeutics·Jorge H VillafañeJosue Fernandez-Carnero
Aug 31, 2011·Journal of Manipulative and Physiological Therapeutics·Josue Fernández-CarneroRoy La Touche Arbizu
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Kevin K Haussler
Jan 21, 2016·Pain Research and Treatment·Andrew D Vigotsky, Ryan P Bruhns
Feb 27, 2009·Journal of Manipulative and Physiological Therapeutics·Kenneth E LearmanChad E Cook
Oct 21, 2015·Journal of Manipulative and Physiological Therapeutics·Hector Beltran-AlacreuRoy La Touche
Dec 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Stephen M OniferCynthia R Long
Jul 29, 2003·Journal of Magnetic Resonance Imaging : JMRI·Krisztina L MaliszaAnthony Wright
Oct 16, 2015·Medical Hypotheses·Kesava Kovanur SampathSteve Tumilty
Mar 26, 2016·The Veterinary Clinics of North America. Equine Practice·Jodie Daglish, Khursheed R Mama
Feb 1, 2005·Manual Therapy·Michel W CoppietersPaul W Hodges
May 7, 2004·Journal of Manipulative and Physiological Therapeutics·Aatit PaungmaliBill Vicenzino
Jun 17, 2006·Manual Therapy·Penny MossAnthony Wright
Jan 7, 2006·Journal of Manipulative and Physiological Therapeutics·Karen R DimmickDavid Newell

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.