Hypoalgesia related to elevated resting blood pressure is absent in adolescents and young adults with a history of functional abdominal pain.

Pain
Stephen BruehlLynn S Walker

Abstract

Elevated resting blood pressure (BP) is hypoalgesic in healthy individuals, but this effect is absent in adults with chronic somatic pain. This study tested whether BP-related hypoalgesia is similarly altered in individuals with a history of chronic visceral pain in childhood. Resting BP was assessed in 94 adolescents and young adults with a known history of childhood functional abdominal pain (FAP) and 55 comparable healthy controls. Responses to an acute heat pain stimulus were then evaluated following exposure to two laboratory stressors. A significant participant type x systolic BP (SBP) interaction (p<.005) revealed that elevated resting SBP was associated with significantly higher heat pain threshold (p<.001) in healthy controls, but was unrelated to pain threshold in the FAP group. A similar pattern was observed for heat pain tolerance, with elevated SBP linked to significantly higher pain tolerance (p<.05) in healthy controls, but unrelated to tolerance in the FAP group. Dysfunction in BP-related hypoalgesia associated with FAP was evident regardless of whether childhood FAP had resolved or still persisted at the time of laboratory testing. Subgroup analyses indicated that BP-related hypoalgesia (in healthy controls) an...Continue Reading

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Citations

Dec 30, 2009·Journal of Behavioral Medicine·Stephen BruehlHeather Cairl
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May 6, 2014·Journal of Behavioral Medicine·Roy Bjørkholt OlsenAudun Stubhaug
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Sep 12, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Helen J BurgessJohn W Burns
Jul 21, 2020·Journal of Hypertension·Elena MakovacCristina Ottaviani

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