Hypoallergenic and non-toxic emollient therapies for children

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Gerd Wolf, Peter H Höger

Abstract

There are many anatomical and functional differences between the skin of young children and adult skin. As a consequence, the skin is more easily irritated by topical agents. There is also increased transcutaneous absorption; the latter effect is amplified by underlying conditions such as ichthyoses and atopic dermatitis with defects of the epidermal barrier. Common topical agents such as salicylic acid and lactic acid can cause life-threatening intoxications. The relevance of transcutaneous absorption of "hidden" ingredients such as polyethylene glycol and preservatives is unknown at present. By emulsifying endogenous barrier lipids, emulsifiers can promote skin dryness. We review the effects of common emollients and their suitability for skin care in children, particularly with the aim to reduce exposure to potential contact allergens and inadvertent emollient activity.

References

Oct 1, 1991·Contact Dermatitis·N Ishiguro, M Kawashima
Mar 1, 1997·Acta Paediatrica·A ChiarettiG Polidori
May 10, 2002·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M GuillotJ M Haguenoer
Apr 2, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Gloor, W Gehring
Jun 20, 2006·Pediatric Dermatology·Manuela Esteban RamírezCarles Luaces Cubells
Oct 14, 2006·The Journal of Investigative Dermatology·Ivone JakasaSanja Kezic

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Citations

Feb 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Flora B de Waard-van der SpekArnold P Oranje
Apr 3, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Schnopp, M Mempel

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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