Hypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteine

Acta histochemica
Ozge UzunPeri Arbak

Abstract

Free radical-mediated injury to lung and pulmonary vasculature is an important mechanism in hypoxia-induced lung damage. In this study, we aimed to investigate the potential protective effects of erdosteine as an antioxidant agent on hypobaric hypoxia-induced pulmonary hypertension. Adult male rats were assigned randomly to three groups. The first group of rats was exposed to hypobaric-hypoxia and the second group was treated with erdosteine (20mg/kg, daily) for 2 weeks, during which time they were in a hypoxic chamber. These groups were compared with normoxic controls. All rats were sacrificed after 2 weeks. The hypoxia-induced increase in right ventricle to left ventricle plus septum weight ratio (from 0.20+/-0.01 to 0.26+/-0.01) was reduced significantly in the erdosteine-treated group (0.23+/-0.01). Malondialdehyde levels were elevated (from 0.33+/-0.11 to 0.59+/-0.02) and total antioxidant status was not changed significantly (from 1.77+/-0.42 to 2.61+/-0.23) by hypoxia. In contrast to the hypoxia-exposed group, malondialdehyde levels were significantly decreased in the erdosteine-treated group (0.37+/-0.02). Total antioxidant status (4.03+/-0.22) was significantly higher in erdosteine-treated rats when compared to non-tre...Continue Reading

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Citations

Oct 1, 2009·International Urology and Nephrology·Talat YurdakulVolkan Kocabas
Jun 5, 2012·Antioxidants & Redox Signaling·Chi-Ming WongYuichiro J Suzuki
Oct 19, 2013·Pharmacology & Therapeutics·David MontaniMarc Humbert
Sep 25, 2009·High Altitude Medicine & Biology·Hui ZhaoYonghui Yang
Apr 16, 2013·Pathology, Research and Practice·Taner YavuzHayriye Ak Yildirim
Oct 12, 2010·Free Radical Biology & Medicine·Margaret B ClarkeEva Nozik-Grayck
Feb 3, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maurizio Moretti, Carlo Felice Marchioni
Jan 10, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Venkat Ratnam DevadasuM N V Ravi Kumar
Jun 23, 2009·Respiratory Medicine·C U AndersenU Simonsen

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