Hypobaric hypoxia induced renal damage is mediated by altering redox pathway

PloS One
Varun ChhabraMaramreddy Prasanna Kumar Reddy

Abstract

Systemic hypobaric hypoxia is reported to cause renal damage; nevertheless the exact pathophysiological mechanisms are not completely understood. Therefore, the present study aims to explore renal pathophysiology by using proteomics approach under hypobaric hypoxia. Six to eight week old male Sprague Dawley rats were exposed to hypobaric hypoxia equivalent to altitude of 7628 metres (pO2-282mmhg) at 28°C and 55% humidity in decompression chamber for different time intervals; 1, 3, and7 days. Various physiological, proteomic and bioinformatic studies were carried out to examine the effect of chronic hypobaric hypoxia on kidney. Our data demonstrated mild to moderate degenerative tubular changes, altered renal function, injury biomarkers and systolic blood pressure with increase in duration of hypobaric hypoxia exposure. Renal proteomic analysis showed 38 differential expressed spots, out of which 25 spots were down regulated and 13 were up regulated in 7 dayhypobarichypoxic exposure group of rats as compared to normoxia control. Identified proteins were involved in specific molecular changes pertinent to endogenous redox pathways, cellular integrity and energy metabolism. The study provides an empirical evidence of renal homeost...Continue Reading

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Citations

Dec 17, 2020·Respiratory Physiology & Neurobiology·Hayarpi JavrushyanArmen Trchounian
Apr 10, 2021·Journal of Physiology and Biochemistry·Ashish K SinghAnil K Pasupulati
Jul 3, 2021·International Journal of Molecular Sciences·Lu XuJiaxing Zhang

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Methods Mentioned

BETA
urine collection
ELISA
electrophoresis
proteomic profiling

Software Mentioned

Mascot engine
STRING db
KEGG
STAT
DELTA
ProteinPilot
Graph Pad
Image J
PANTHER
STRING

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