Hypocalcemia may not be essential for the development of secondary hyperparathyroidism in chronic renal failure

The Journal of Clinical Investigation
S Lopez-HilkerE Slatopolsky

Abstract

Hypocalcemia is the main factor responsible for the genesis of secondary hyperparathyroidism in chronic renal disease. Studies with parathyroid cells obtained from uremic patients indicate that there is a shift in the set point for calcium-regulated hormone (parathyroid hormone [PTH] secretion. Studies were performed in dogs to further clarify this new potential mechanism. Hypocalcemia was prevented in uremic dogs by the administration of a high calcium diet. Initially, ionized calcium was 4.79 +/- 0.09 mg/dl and gradually increased up to 5.30 +/- 0.05 mg/dl. Despite a moderate increase in ionized calcium, immunoreactive PTH (iPTH) increased from 64 +/- 7.7 to 118 +/- 21 pg/ml. Serum 1,25(OH)2D3 decreased from 25.4 +/- 3.8 to 12.2 +/- 3.6 pg/ml. Further studies were performed in two other groups of dogs. One group received 150-200 ng and the second group 75-100 ng of 1,25(OH)2D3 twice daily. The levels of 1,25(OH)2D3 increased from 32.8 +/- 3.5 to a maximum of 69.6 +/- 4.4 pg/ml. In the second group the levels of serum 1,25(OH)2D3 after nephrectomy remained normal during the study. Amino-terminal iPTH did not increase in either of the two groups treated with 1,25(OH)2D3. In summary, the dogs at no time developed hypocalcemia; h...Continue Reading

References

Feb 17, 1975·Biochemical and Biophysical Research Communications·H L Henry, A W Norman
Nov 1, 1976·Steroids·J F CloixJ L Funck-Brentano
Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·F LlachE Reiss
Jan 5, 1978·The New England Journal of Medicine·J FreitagE Slatopolsky
Sep 1, 1978·Kidney International·P J Somerville, M Kaye
Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·E M BrownG D Aurbach
Oct 22, 1976·Biochimica Et Biophysica Acta·J G HaddadT J Hahn
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·F Llach, S G Massry
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J SilverL M Sherwood
Aug 1, 1973·Kidney International·J W CoburnS G Massry
Feb 1, 1973·Archives of Biochemistry and Biophysics·Y Tanaka, H F Deluca
Mar 1, 1971·The Journal of Clinical Investigation·E SlatopolskyN S Bricker
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T A ReinhardtB W Hollis
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S MadsenJ Ladefoged
Jan 1, 1982·The Journal of Clinical Endocrinology and Metabolism·E M BrownS P Marynick
Jul 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·B TennantJ B Tasker
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·E Bellorin-FontS Klahr

❮ Previous
Next ❯

Citations

May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M CloutierP D'Amour
Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H JüppnerJ Brodehl
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisM N Beneton
Oct 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M WallotM Bald
Feb 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J A KanisN A Hamdy
Jan 14, 2000·Kidney International. Supplement·J A Kanis
Apr 27, 1989·The New England Journal of Medicine·J W Coburn, I B Salusky
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marianne RixKlaus Olgaard
Apr 29, 1998·The Journal of Small Animal Practice·P J Barber, J Elliott
Feb 11, 1995·BMJ : British Medical Journal·N A HamdyI T Fairey
Mar 24, 2006·Nephron. Experimental Nephrology·Luis Perez-RuizJose M Valdivielso
Oct 1, 1990·The Journal of Clinical Investigation·T Naveh-Many, J Silver
Jun 20, 1998·Journal of Endocrinological Investigation·H FunahashiH Takagi
Jan 1, 1997·Calcified Tissue International·J A Kanis
Nov 8, 2003·Wiener klinische Wochenschrift·Otmar JankoGeorg Biesenbach
Feb 26, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Cynthia S Ritter, Eduardo Slatopolsky
Aug 1, 1987·The American Journal of the Medical Sciences·N A Breslau
May 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D B LeeJ W Coburn
Mar 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M Hakim, J M Lazarus
Apr 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A Delmez, E Slatopolsky
Aug 1, 1988·Kidney International·S PatelC H Hsu
Dec 1, 1988·Kidney International·L D QuarlesB Lobaugh
Jun 1, 1988·Kidney International·D A Feinfeld, L M Sherwood
May 1, 1988·Kidney International·S Hirschel-ScholzJ P Bonjour
Mar 1, 1989·Kidney International·A DussoE Slatopolsky
Sep 1, 1988·Kidney International·A DussoE Slatopolsky
Aug 1, 1990·Kidney International·H Malluche, M C Faugere
May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Llach
Oct 1, 1992·Trends in Endocrinology and Metabolism : TEM·J P BonjourR Rizzoli
Oct 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J Marx, J Barsony
Oct 1, 1993·Bioscience Reports·G JablonskiJ O Gordeladze
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L D Quarles, O S Indridason
May 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A FriedlanderR L Horst
Jan 26, 2007·Journal of the American Society of Nephrology : JASN·Kevin J Martin, Esther A González
Jun 1, 1989·The American Journal of Physiology·G N HendyD Goltzman

❮ Previous
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