Hypochlorite scavenging activity of flavonoids

The Journal of Pharmacy and Pharmacology
Omidreza FiruziL Saso

Abstract

Scavengers of hypochlorite, a highly reactive oxidant produced by activated phagocytes, could have potential therapeutic effects in diseases in which this oxidant plays a pathogenic role. Flavonoids are polyphenolic substances present in food plants and have been extensively studied for their antioxidant properties against various free radicals. Less is known about their reactivity with hypochlorite. In this study, the hypochlorite scavenging activity of flavonoids was investigated using a microplate assay recently developed in our laboratory. This method evaluates the ability of a substance to inhibit the formation of chloramines in human serum albumin upon oxidation by hypochlorite. Thirteen flavonoids were tested. Most of them inhibited human serum albumin oxidation at micro-molar concentrations and appeared more active than Trolox, a water-soluble equivalent of vitamin E. It was observed that the greater the number of hydroxyl substitutions, the greater the scavenging activity. The 3-hydroxy substitution seemed to be particularly important for scavenging activity, whereas the presence of a 2,3-double bond in the C ring did not. Flavonoids were found to be good hypochlorite scavengers in-vitro and further information is prov...Continue Reading

References

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·F Shahidi, P K Wanasundara
Jan 1, 1991·Free Radical Biology & Medicine·G SichelR P Bonomo
Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Jan 1, 1993·Free Radical Research Communications·B C ScottO I Aruoma
Sep 25, 1995·Biochemical and Biophysical Research Communications·S A van AckerA Bast
Oct 1, 1995·Free Radical Biology & Medicine·A SaijaF Castelli
Jun 1, 1994·Free Radical Biology & Medicine·Y HanasakiS Fukui
Aug 17, 1994·Biochemical Pharmacology·L MiraC F Manso
Jul 1, 1993·Free Radical Biology & Medicine·C A Rice-Evans, A T Diplock
Mar 15, 1996·The Journal of Clinical Investigation·L J HazellR Stocker
Jan 1, 1996·Free Radical Biology & Medicine·J A Berliner, J W Heinecke
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Jan 1, 1997·Free Radical Biology & Medicine·G CaoR L Prior
Jul 30, 1997·Biochemical and Biophysical Research Communications·G R HaenenA Bast
Jul 1, 1998·Fundamental & Clinical Pharmacology·H de Groot, U Rauen
Sep 1, 1999·Free Radical Biology & Medicine·A C BlackburnG D Buffinton
Aug 5, 2000·Journal of Natural Products·P G Pietta
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J H MoonJ Terao
Oct 6, 2000·Free Radical Biology & Medicine·C C Winterbourn, A J Kettle
Apr 5, 2002·Phytotherapy Research : PTR·D A Daels-RakotoarisonJ-C Cazin
Aug 9, 2002·Journal of Agricultural and Food Chemistry·Patrícia ValentãoM Lourdes Bastos
Feb 21, 2003·Free Radical Research·M Manuela SilvaLurdes Mira
Feb 1, 1997·Redox Report : Communications in Free Radical Research·A J Kettle, C C Winterbourn

❮ Previous
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Citations

Oct 17, 2013·The International Journal of Biochemistry & Cell Biology·Divyashree RavishankarHelen M I Osborn
Jun 26, 2013·Food Chemistry·Justyna SiwakGrzegorz Bartosz
Mar 2, 2006·Chemical & Pharmaceutical Bulletin·Wimal HerathIkhlas Ahmad Khan
Feb 1, 2011·Fitoterapia·D ProcházkováN Wilhelmová
Nov 11, 2008·Toxicology·Premysl MladenkaRadomír Hrdina
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Jens Z PedersenLuciano Saso
Apr 15, 2016·Redox Report : Communications in Free Radical Research·Tomáš FilipskýPřemysl Mladěnka
Jun 28, 2015·International Journal of Biological Macromolecules·Justyna Krych-Madej, Lidia Gebicka
May 1, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lidia Gebicka, Ewa Banasiak
May 27, 2016·Free Radical Research·Justyna Krych-MadejLidia Gebicka
Jul 26, 2018·Journal of Biomolecular Structure & Dynamics·Fakhra Amin, Bilqees Bano
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Razieh HosseiniOmidreza Firuzi
Jan 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Neda Nićiforović, Helena Abramovič
Jun 5, 2021·Plant Physiology and Biochemistry : PPB·Priyanka SinghShamsul Hayat

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