PMID: 20626336Jul 16, 2010Paper

Hypocholesterolemia

Current Vascular Pharmacology
Elisavet MoutzouriEvangelos N Liberopoulos

Abstract

Hypocholesterolemia is defined as total cholesterol (TC) and low density cholesterol (LDL-C) levels below the 5(th) percentile of the general population adjusted for age, gender and race. Hypocholesterolemia may be attributed to inherited disorders or several secondary causes. Inherited forms of hypocholesterolemia consist of a group of rare diseases. The best studied are familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia (ABL). Clinical diagnosis rests on lipid levels and the pattern of inheritance after secondary causes are excluded. Patients with primary hypobetalipoproteinemias may manifest a variety of symptoms and signs affecting several organs (steatorrhea, neurological and ophalmological symptoms, non-alcoholic fatty liver disease) or be asymptomatic. Understanding hypocholesterolemia and the underlying molecular basis is of crucial importance since this may provide new insights in the treatment of hypercholesterolemia and cardiovascular disease.

Citations

Jan 15, 2013·Journal of Clinical Lipidology·Aris P AgouridisMoses S Elisaf
Aug 5, 2015·International Journal of Cardiology·Chidozie NdukaSaverio Stranges
Dec 3, 2014·Psychiatry Research·Maria da Graça CantarelliCarlos-Alberto Gonçalves
Feb 5, 2013·The American Journal of Cardiology·John C LaRosaScott M Wasserman
Dec 22, 2019·European Journal of Clinical Investigation·Gjin NdrepepaAdnan Kastrati
May 10, 2017·Infection·Sebastian Filippas-NtekouanMoses Elisaf
Jul 12, 2021·Clinical Biochemistry·Vrajesh PandyaJoseph W Rudolf

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