Hypocomplementemic urticarial vasculitis syndrome.

Current Rheumatology Reports
Luis J JaraMiguel A Saavedra

Abstract

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is an uncommon immune complex-mediated entity characterized by urticaria with persistent acquired hypocomplementemia. First described in 1973, HUVS is associated with several systemic findings including leukocytoclastic vasculitis, severe angioedema, laryngeal edema, pulmonary involvement, arthritis, arthralgia, glomerulonephritis, and uveitis. These manifestations should be present for at least 6 months. Laboratory findings include low complement levels of classical pathway, namely C1q, C2, C3, and C4. The disease marker is the serum presence of anti-C1q antibodies. Treatment, based on disease severity, involves corticosteroids and other immunosuppressive agents that have demonstrated some success. Patients may have significant morbidity and mortality, most commonly caused by chronic obstructive pulmonary disease and acute laryngeal edema.

References

Sep 1, 1989·Arthritis and Rheumatism·J J Wisnieski, G B Naff
Jan 1, 1987·Nephron·G RamirezL Espinoza
Nov 1, 1986·Journal of the American Academy of Dermatology·J S FortsonG C Groggel
May 1, 1984·The Journal of Allergy and Clinical Immunology·L R LopezA L Schocket
Jul 1, 1982·The British Journal of Dermatology·J P Callen, S Kalbfleisch
Jul 1, 1994·Arthritis and Rheumatism·J J WisnieskiE R McFadden
Jun 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Werder, B Truniger
Apr 16, 1998·European Journal of Pediatrics·M RenardW Proesmans
Jan 27, 2000·Current Opinion in Rheumatology·J J Wisnieski
Jul 25, 2000·Immunopharmacology·U Kishore, K B Reid
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P GrimbertP Lang
Sep 12, 2002·Clinical Reviews in Allergy & Immunology·Joe VenzorDavid P Huston
Oct 25, 2003·Journal of the American Academy of Dermatology·Kapil SaigalFrancisco A Kerdel
Feb 10, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H N Gandhi, C K Roseblade
May 4, 2004·Immunology and Allergy Clinics of North America·Mark D P Davis, Jerry D Brewer
May 15, 2004·Medical Hypotheses·Lit-Hung Leung
Jun 29, 2005·The Journal of Investigative Dermatology·Richard D SontheimerDoina M Racila
Apr 25, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Staubach-RenzK Steinbrink
Mar 12, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C V P DincyE P Eapen
Jul 9, 2008·Autoimmunity Reviews·Cees G M Kallenberg
Oct 1, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leah BalsamSofia Rubinstein
Mar 10, 2009·Journal of Korean Medical Science·Min Young HerDong Yook Kim
Apr 21, 2009·Journal of the Neurological Sciences·Massimiliano FilostoAlessandro Padovani
Jun 9, 2009·The Journal of Allergy and Clinical Immunology·Atul Khasnis, Carol A Langford

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Citations

Sep 11, 2012·Autoimmunity Reviews·Angelo V MarzanoEmilio Berti
Jul 22, 2011·The New England Journal of Medicine·Daniela KroshinskyRosalynn M Nazarian
Dec 1, 2014·Annales de dermatologie et de vénéréologie·C KoudoukpoJ-D Bouaziz
Apr 8, 2014·Neurologic Clinics·David S Younger
Mar 19, 2014·Pediatric Clinics of North America·Tracy V Ting
Nov 8, 2015·Autoimmunity Reviews·Marcella PreteFederico Perosa
Sep 16, 2015·Annales de dermatologie et de vénéréologie·B Flageul
Oct 15, 2014·Clinical Reviews in Allergy & Immunology·Maria Sole ChimentiRoberto Perricone
Apr 23, 2016·Journal of Cutaneous Pathology·Shu Min WongLynette Chee
Feb 18, 2015·Frontiers in Medicine·Jaana Panelius, Seppo Meri
Apr 28, 2016·Current Rheumatology Reports·Giuseppe LopalcoLuca Cantarini
Dec 30, 2014·Annales de dermatologie et de vénéréologie·M-S Doutre
Sep 29, 2011·Journal of Thoracic Imaging·Akshat C Pujara, Tan-Lucien H Mohammed
Oct 9, 2018·Arthritis Care & Research·Kimberly DeQuattroMary Margaretten
Aug 17, 2019·Italian Journal of Pediatrics·Carlo CaffarelliFabio Cardinale
Aug 3, 2019·Clinical & Experimental Ophthalmology·Rebecca W LiongSharon Morris
Jan 29, 2020·Journal of Clinical Pharmacy and Therapeutics·Yoshiro HoraiAtsushi Kawakami
Aug 16, 2015·International Journal of Dermatology·Mariko TakaoKeiji Iwatsuki
Jul 10, 2020·Journal of Clinical Medicine·Oana IonIoanel Sinescu
Jul 29, 2020·International Journal of Dermatology·Darshana BalasubramaniamMohammed Ahmed
Dec 22, 2020·Frontiers in Medicine·Gabriella Moroni, Claudio Ponticelli
Mar 31, 2021·The Journal of Experimental Medicine·Johannes HartlBoris Reizis
May 12, 2021·BMJ Case Reports·Ella Claire BerryAnthea Anantharajah
Jul 6, 2021·International Journal of Women's Dermatology·Stephanie L Gu, Joseph L Jorizzo

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