Hypocrellin B and nano silver loaded polymeric nanoparticles: Enhanced generation of singlet oxygen for improved photodynamic therapy

Materials Science & Engineering. C, Materials for Biological Applications
Subramanian NatesanRajaguru Palanisamy

Abstract

A nanoparticulate photodynamic approach was employed with an objective to achieve enhanced production of singlet oxygen ((1)O2), for the management of posterior segment eye diseases like age related macular degeneration. The hypocrellin B (HB) loaded poly lactide-co-glycolide nanoparticle formulations were incorporated with nano silver (HBS-NPs). The optimized HBS-NPs contained 2.60±0.06mg/mL of HB and showed (i) 135.6 to 828.2nm size range, and (ii) negative zeta potential with a narrow polydispersity index. The DSC thermograms suggested the amorphous nature of HB inside the HBS-NPs. With the average encapsulation efficiency of 92.9±1.79%, the drug release from the HBS-NPs followed a biphasic pattern with an initial burst of 3.50% during first 8h followed by a sustained release of 47.82% within 3days. The interaction between nano silver and HB as assessed by the increase in spectral intensity of Raman spectrum demonstrates that HB may be attached over the nano silver. Generation of reactive oxygen species (ROS) by HBS-NPs was significantly higher than that of HB/HB-NPs. The singlet oxygen generating efficiency assessed using EPR spectrometer follows the order of nano silver>HB-NPs>pure HB drug solution>HBS-NPs. The HBS-NPs had...Continue Reading

Citations

Nov 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Krzysztof SztanderaBarbara Klajnert-Maculewicz
Jan 17, 2021·Photodiagnosis and Photodynamic Therapy·Ivan S Mfouo-TyngaCristina Kurachi

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