Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii

Natural Product Research
Li-Jian DingShi-Hai Xu

Abstract

In continuation of our search for new antibacterial and antioxidant metabolites from sponge-derived fungi, one new tyrosol derivative, hypocrol A (1), together with four known congeners, trichodenol B (2), 4-hydroxyphenethyl acetate (3), 4-hydroxyphenethyl tetradecanoate (4) and 1-oleyltyrosol (5), was isolated from the strain Hypocrea koningii PF04. Their planar structures were unequivocally elucidated by spectroscopic methods and comparison with the literature data. All the compounds displayed weak antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus and Escherichia coli, whereas compounds 1 and 2 exhibited a moderate antioxidant efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay with IC50 values of 48.5 and 97.4 μg/mL, respectively.

References

Feb 21, 2004·Natural Product Research·Armandodoriano BiancoNicola Uccella
Oct 30, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X-J ChengR-L Zhou
Jun 7, 2011·Natural Product Research·Tao LiuHui-Ming Hua

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Citations

Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Mei ChengGuo-Qiang Li
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 27, 2021·Marine Drugs·Roberta EspositoMaria Costantini

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