PMID: 7018579Apr 14, 1981Paper

Hypodermin A, a trypsin-like neutral proteinase from the insect Hypoderma lineatum

Biochimica Et Biophysica Acta
N T TongB Keil

Abstract

Hypodermin A, a serine proteinase from the larva Hypoderma lineatum, with a molecular weight of 27 000 was obtained in pure form by ion-exchange chromatography. It is inhibited by diisopropyl phosphofluorate, a serine proteinase inhibitor, but not by metallo or cysteine enzyme inhibitors such as EDTA or thiol reagents. In the same way, it is fully inactivated by trypsin inhibitors, but not by specific chymotrypsin inhibitors. Its specificity, limited to carboxyl side of arginine residue in B-chain of insulin, is more complicated on other polypeptide substrates. Sequence analysis suggests structural homology with H. lineatum collagenase as well as with other members of the trypsin family.

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Citations

Aug 1, 1994·Molecular and Biochemical Parasitology·N MoiréC Boulard
Sep 28, 2002·International Journal for Parasitology·Domenico Otranto, Jamie R Stevens
Feb 27, 1999·International Journal for Parasitology·J H Pruett
Oct 17, 2006·Parasitology Today·N Moiré
Jan 15, 2014·Parasitology International·Ren-Jin ChenXiao-Rong Zhu
Jan 27, 2015·Veterinary Parasitology·Rosario Panadero-Fontán, Domenico Otranto
Jun 25, 2009·Revista Do Instituto De Medicina Tropical De São Paulo·Jomara Mendes GonçalvesAntonio César Rios Leite
Dec 1, 1988·International Journal of Peptide and Protein Research·E SakalY Birk

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