Hypoferremia is Associated With Increased Hospitalization and Oxygen Demand in COVID-19 Patients

HemaSphere
T. HippchenUta Merle

Abstract

Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore, we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n = 204), inpatients (cohort B, n = 81), and outpatients later admitted to hospital because of health deterioration (cohort C, n = 23). Iron metabolism parameters were severely altered in patients of cohort B and C compared to cohort A. In multivariate regression analysis including age, gender, CRP and iron-related parameters only serum iron and ferritin were significantly associated with hospitalization. ROC analysis revealed an AUC for serum iron of 0.894 and an iron concentration <6 μmol/l as the best cutoff-point predicting hospitalization with a sensitivity of 94.7% and a specificity of 67.9%. When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Unexpectedly, serum iron levels poorly correlate wit...Continue Reading

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Citations

Aug 4, 2021·Journal of Medicinal Chemistry·Essam Eldin A OsmanNouri Neamati
Aug 15, 2021·Seminars in Hematology·Silvia ColucciSandro Altamura
Aug 15, 2021·Seminars in Hematology·Domenico GirelliAlice Vianello
Oct 13, 2021·Journal of Neural Transmission·P RiedererJ Sian-Hülsmann

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

GraphPad prism
SPSS
GraphPad

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