Hypofractionated accelerated computed tomography-guided interstitial high-dose-rate brachytherapy for liver malignancies

Brachytherapy
Nikolaos TselisNikolaos Zamboglou

Abstract

To report our results of computed tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy (BRT) in the local treatment of inoperable primary and secondary liver malignancies. Between 2000 and 2009, 31 patients underwent a total of 42 BRT procedures for 36 hepatic lesions exceeding 4 cm and located adjacent to the liver hilum and bile duct bifurcation. The median tumor volume was 99 cm(3) (range, 46-1348 cm(3)). The median age was 64 years (range, 27-85 years). The HDR-BRT delivered a median total physical dose of 13.0 Gy (range, 7.0-32.0 Gy) in twice daily fractions of median 7.0 Gy (range, 4.0-10.0 Gy) in 14 patients and in once daily fractions of median 8.0 Gy (range, 7.0-14.0 Gy) in 17 patients. The median followup was 13.3 months with an overall survival rate of 66% at 1 year. The local control rate for patients with metastatic lesions was 79%, 59%, and 59%, and for the subgroup with primary hepatic tumors 88%, 50%, and 50% at 1, 2, and 3 years, respectively. Severe side effects occurred in 4.7% of BRT procedures with no treatment-related deaths. Our results confirm CT-guided interstitial HDR-BRT to be a safe procedure for the local treatment of inoperable liver malignancies unsuitable for thermal ablation.

References

Oct 16, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C KolotasN Zamboglou
Jan 16, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J WulfM Flentje
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Laura A DawsonRandall K Ten Haken
Nov 19, 2003·Japanese Journal of Clinical Oncology·Joon Oh ParkKeunchil Park
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Daniel JaeckPhilippe Wolf
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Jens RickeRoland Felix
Nov 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·Jens RickeRoland Felix
Mar 9, 2005·European Radiology·Elisabetta BuscariniAlessandro Zambelli
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Jens RickePeter Wust
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Tracey E SchefterLaurie E Gaspar
Dec 21, 2005·Surgery·Mehrdad NikfarjamChristopher Christophi
Sep 20, 2006·Acta Oncologica·Morten HoyerHans Von der Maase
Sep 20, 2006·Acta Oncologica·Brian D KavanaghLaurie E Gaspar
Jan 2, 2007·International Journal of Radiation Oncology, Biology, Physics·Alan W KatzPaul Okunieff
Oct 31, 2007·Cardiovascular and Interventional Radiology·Erwan PauletPhilippe L Pereira
Jul 9, 2009·Journal of Vascular and Interventional Radiology : JVIR·S Nahum GoldbergUNKNOWN Society of Interventional Radiology Technology Assessment Committee and the International Working Group on Image-guided Tumo
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Konrad MohnikeJens Ricke
Jan 23, 2010·The British Journal of Surgery·A E M van der PoolJ N M Ijzermans
Feb 16, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S StintzingA Muacevic
Mar 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Robert B CaseLaura A Dawson
Mar 31, 2010·International Journal of Radiation Oncology, Biology, Physics·Karyn A GoodmanAlbert C Koong
Aug 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Cynthia L EcclesLaura A Dawson
Jan 25, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nikolaos TselisNikolaos Zamboglou

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Citations

Nov 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Federico CollettiniBernhard Gebauer
Jan 16, 2020·Journal of Cancer Research and Therapeutics·Zhaomin SongWujie Wang
Dec 29, 2020·Brachytherapy·Michael R FolkertRanjan Kumar Sur

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