Hypofractionated conformal HDR brachytherapy in hormone naïve men with localized prostate cancer. Is escalation to very high biologically equivalent dose beneficial in all prognostic risk groups?

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Razvan M GalalaeBernhard Kimming

Abstract

To analyze the long-term effect of local dose escalation using conformal hypofractionated high-dose-rate brachytherapy (HDR-BT) boost and pelvic external-beam radiation therapy (EBRT) in hormone-naïve men with localized prostate cancer. A total of 579 men were consecutively treated with pelvic EBRT and dose escalating HDR-BT since 1986 in two prospective trials: 378 patients at William Beaumont Hospital (1991-2002), and 201 patients at Kiel University (1986-1999). BT optimization was done modulating both, the dwell times and spatial source positions. A short course of neoadjuvant/concurrent androgen deprivation therapy was given to 222 patients. Hormone-naïve patients only (n = 324) with a follow-up > or = 18 months were analyzed. All patients had at least one poor prognostic factor (stage > or = T2b, Gleason Score > or = 7, pretreatment prostate-specific antigen [PSA] > or = 10 ng/ml): any one factor 122 patients, any two factors 122 patients, and three factors 80 patients. This cohort was stratified by equivalent dose (ED): dose level 1, < or = 94 Gy, n = 58, and dose level 2, > 94 Gy, n = 266, assuming an alpha/beta ratio of 1.2. The ASTRO definition for biochemical failure was used. Mean follow-up was 5.3 years (1.5-13.9 ye...Continue Reading

Citations

Jun 22, 2006·Der Urologe. Ausg. A·M SchenckM Stuschke
Feb 21, 2008·Der Urologe. Ausg. A·S H StübingerR Galalae
Sep 11, 2013·Nature Reviews. Urology·Nicholas G ZaorskyRobert B Den
Jun 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Markus Karl Alfred HerrmannAndrea Hille
Oct 5, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frederik WenzThomas Wiegel
Jul 4, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Víctor Macías, Albert Biete
Mar 28, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·N TselisG Chatzikonstantinou
Jul 1, 2017·Nature Reviews. Urology·Nicholas G ZaorskyEric M Horwitz
May 27, 2011·Acta Oncologica·Ulrika HarmenbergSten Nilsson
Sep 5, 2009·Advances in Urology·Georgios KoukourakisVassilios Kouloulias
Nov 6, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Anastassia LöserRudolf Schwarz

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