Abstract
Radiotherapy alone is often used to treat early-stage glottic cancer (ESGC); however, the optimal radiation treatment schedule remains unknown. The National Comprehensive Cancer Network (NCCN) guidelines recommend both hypofractionated radiotherapy (HFX) and conventionally fractionated radiotherapy (CFX). We compared overall survival (OS) and treatment patterns among patients treated with HFX vs CFX for ESGC using a large national database. We identified patients diagnosed with stage I-II (cT1-2N0M0) glottic cancer from 2004 to 2013 within the National Cancer Data Base who were treated with either HFX (2.25 Gy/fraction to 63-65.25 Gy) or CFX (2.0 Gy/fraction to 66-70 Gy). The overall survival of patients receiving HFX vs CFX was compared using the log-rank test, multivariable Cox proportional hazards regression, and propensity score matching. All statistical tests were two-sided. Among 10 212 included patients, 4030 patients (39.5%) received HFX and 6182 patients (60.5%) received CFX. Predictors for receipt of HFX included clinical T1 disease, recent year of diagnosis, and treatment at academic and higher-volume centers (all P < .001). Patients treated with HFX increased from 22.1% in 2004 to 58.0% in 2013. HFX was associated w...Continue Reading
References
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Q T LeT L Phillips
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·J C van der VoetH Bartelink
Oct 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M MendenhallR W Hinerman
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Adam S GardenK Kian Ang
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Raghavendra V GowdaNicholas J Slevin
Apr 28, 2004·Cancer·William M MendenhallDouglas B Villaret
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Hideya YamazakiMasashi Chatani
Sep 5, 2006·Lancet·Jean BourhisUNKNOWN Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group
Apr 2, 2008·The British Journal of Radiology·R M WyattR G Dale
Apr 21, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·N L C CheahJ Glaholm
Jan 19, 2012·Cancer·Claudio Dansky UllmannJennifer L Stevens
Apr 16, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mingsi LiJoseph Scharpf
May 23, 2013·Head & Neck·John A RidgeJonathan J Beitler
Oct 29, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sung Ho MoonJin Hee Kim
Mar 19, 2014·Cancer·Stephanie MisonoBeth A Virnig
Mar 29, 2014·Head & Neck·Atsushi MotegiTetsuo Akimoto
Jul 19, 2014·International Journal of Radiation Oncology, Biology, Physics·Andy TrottiK Kian Ang
Nov 9, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·William M MendenhallAlfio Ferlito
Aug 11, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nina M LyhneJens Overgaard
Sep 24, 2015·Radiation Oncology·Ekin ErmişRobin Jd Prestwich
Citations
Nov 10, 2017·Journal of the National Cancer Institute·Jens Overgaard
Jul 4, 2019·Radiation Oncology Journal·Jeong Won LeeDongbin Ahn
Jan 25, 2020·Head & Neck·Assaf MooreDaniel A Goldstein
May 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rony BensonSupriya Mallick
May 8, 2018·Cancer Medicine·Cheng ZhanLi Yan
Oct 17, 2019·Frontiers in Oncology·Olgun ElicinMehmet Şen
Jun 20, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A Mucha-MałeckaK Małecki
Nov 12, 2019·Frontiers in Oncology·Olgun ElicinGuido Henke
Dec 18, 2019·Cancers·Mark C KorpicsMichael T Spiotto
Nov 28, 2020·Nature Reviews. Disease Primers·Daniel E JohnsonJennifer R Grandis
Apr 7, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Guan-Jiang Huang, Bei-Bei Yang
May 2, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M TonneauX Liem
Aug 17, 2021·Risk Management and Healthcare Policy·Jialing WuYimin Liu
Sep 8, 2021·Scientific Reports·Anna Mucha-MałeckaMaciej Modrzejewski
Feb 8, 2018·International Journal of Radiation Oncology, Biology, Physics·Jens Overgaard
Feb 8, 2018·International Journal of Radiation Oncology, Biology, Physics·William A Stokes, Sana D Karam