PMID: 8951509Jan 1, 1996Paper

Hypofractionated radiotherapy with concurrent 5-fluorouracil radiosensitisation for recurrent or locally advanced colorectal cancer. A phase II study

International Journal of Colorectal Disease
J SkarlatosD Yannakakis

Abstract

In a pilot study we treated 19 patients suffering from recurrent or locally advanced inoperable colorectal cancer, with concurrent hypofractionated radiotherapy (4-5 Gy/fraction, 2 fractions per week) and 5-fluorouracil bolus, 1 hour before RT at doses of 300 mg/m2. For 16 patients treated with radical intent the Normalised Total Dose for alpha/beta = 10 Gy ranged between 56-74 Gy (median 62 Gy). The schedule used was very well tolerated. Moderate grade II haematological toxicity was observed in 11% of cases and diarrhoea grade II/III resulting in 2-4 weeks treatment delay was observed in 26% of cases. One case with bowel perforation and one with painful subcutaneous fibrosis was observed during 12-27 months of follow-up. Out of 16 patients treated with radical intent 4 (25%) showed complete response and the overall response rate was 56% (9/16). The one-year symptom-free survival was obtained in 11/16 (69%) radically treated patients. It is concluded that hypofractionated radiochemotherapy with 5-fluorouracil for recurrent or locally advanced colorectal cancer is an effective regimen and has acceptable acute and late toxicity. Further investigation is required.

Citations

Dec 18, 1998·American Journal of Clinical Oncology·M I KoukourakisE Helidonis
Jul 17, 2009·Expert Opinion on Investigational Drugs·Teni Boulikas
Oct 29, 2005·International Journal of Radiation Oncology, Biology, Physics·Yu-Jen ChenMing-Shi Shiao
Oct 15, 2018·Oncology Research and Treatment·Mateusz Spałek, Lucjan Wyrwicz

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