Hypofractionated stereotactic body radiotherapy for localized prostate cancer - first Nordic clinical experience

Acta Oncologica
Kristiina KoskelaVesa Kataja

Abstract

The use of hypofractionated stereotactic body radiotherapy (SBRT) as primary treatment modality in clinically localized prostate cancer (PCa) is emerging, because the low α/β-ratio favors the use of high dose per fraction in PCa. There is a need for more data about SBRT, especially in high-risk PCa patients. The purpose of this retrospective study was to evaluate the safety and the short-term efficacy of robotic SBRT in a clinical patient cohort with localized PCa including also high-risk patients (D'Amico risk stratification). A total of 240 consecutive patients with clinically localized PCa were treated primarily with SBRT to total doses of 35 Gy or 36.25 Gy in 5 fractions using a robotic SBRT device (CyberKnife(®)). All risk groups (D'Amico risk stratification) were represented as follows: 48 (22%), 59 (27%) and 111 (51%) of the patients representing low-, intermediate- and high-risk group, respectively. Data on acute and intermediate-term toxicities and early PSA responses were analyzed. Neither acute grade 3 or higher GU nor rectal toxicity was observed. Regardless of the fact that 29 (13.3%) patients experienced intermediate-term toxicity requiring diagnostic interventions, the rates of intermediate-term grade 3 GU, recta...Continue Reading

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Citations

Oct 17, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Yasemin Cihan
Aug 30, 2019·Technology in Cancer Research & Treatment·Leszek MiszczykAndrzej Tukiendorf
Jul 16, 2020·Radiation Oncology·Kristiina VuolukkaVesa Kataja
May 3, 2020·Nature Reviews. Urology·Yiannis PhilippouRichard J Bryant
Sep 10, 2020·International Journal of Radiation Oncology, Biology, Physics·Trevor J RoyceRonald C Chen
Jul 19, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Graff, G Crehange
Aug 24, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Paul NguyenPhilippe Nickers

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